SML3909
SGC-CK2-2
≥98% (HPLC)
Synonym(s):
5-(Benzylamino)pyrimido[4,5-c]quinoline-8-carboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C19H14N4O2
CAS Number:
Molecular Weight:
330.34
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
SGC-CK2-2 is a highly potent and selective casein kinase 2 (CK2, CKII) inhibitor (IC50 = 3 nM/CK2α and <1 nM/CK2α by enzyme assay; CK2α/CK2α′ IC50 = 920/200 nM by cellular NanoBRET; genomewide by DiscoverX scanMAX panel at 1 μM). SGC-CK2-2 effectively inhibits CK2 downstream signaling in MDA-MB-231 cells (AKT pS129 IC50 ~5 μM post 24h) without cytotoxicity (up to 10 μM & 48h).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2
ACS Medicinal Chemistry Letters, 14(4), 432-441 (2023)
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