SML1135

MG-132(R)

≥95% (HPLC)

• Synonym(s): Z-L-Leu-D-Leu-L-Leu-al
• Empirical Formula (Hill Notation): C₂₆H₄₁N₃O₅
• CAS Number: 1211877-36-9
• Molecular Weight: 475.62
• MDL number: MFCD28580122
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825671
• NACRES: NA.32

Properties

• product line: SAFC Hitech^®
• Quality Level: 200
• Assay: ≥95% (HPLC)
• form: powder
• solubility: DMSO: soluble
• storage temp.: −20°C
• SMILES string: O=C(N[C@H](CC(C)C)C(N[C@H](C=O)CC(C)C)=O)[C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O
• InChI: 1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22+,23-/m0/s1
• InChI key: TZYWCYJVHRLUCT-ZRBLBEILSA-N
• Gene Information: human ... CTSB(1508) , NFKB1(4790) , PSMA1(5682)

Description

Biochem/physiol Actions

MG-132(R) is a potent, membrane-permeable proteasome inhibitor. It induces neurite outgrowth in PC12 cells at 10 M. MG-132(R) blocks cleavage of poly(ADP-ribose) polymerase and apoptosis in thymocytes. However, MG-132(R) also activates c-Jun N-terminal protein kinase (JNK-1), which initiates apoptosis in response to cell stress. Proteasome inhibition induces accumulation of heat shock protein mRNA, activation of heat-shock proteins, and enhanced thermotolerance in various cell types.

Legal Information

SAFC Hitech is a registered trademark of Sigma-Aldrich Co. LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable