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P9547

Sigma-Aldrich

Prilocaine hydrochloride

≥98% (TLC)

Synonym(s):

N-(2-Methylphenyl)-2-(propylamino)propanamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C13H20N2O · HCl
CAS Number:
1786-81-8
Molecular Weight:
256.77
EC Number:
217-244-0
MDL number:
MFCD00079279
UNSPSC Code:
12352200
PubChem Substance ID:
57654573
NACRES:
NA.77

Quality Level

200

Assay

≥98% (TLC)

form

powder

originator

AstraZeneca

SMILES string

Cl[H].CCCNC(C)C(=O)Nc1ccccc1C

InChI

1S/C13H20N2O.ClH/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2;/h5-8,11,14H,4,9H2,1-3H3,(H,15,16);1H

InChI key

BJPJNTKRKALCPP-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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Biochem/physiol Actions

Used for local nerve block and for spinal anesthesia; pharmacological properties are similar to those of lidocaine.

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0001421349
1421349V
1421349
1415452
038K1898

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Nezih Sertoz et al.
Foot & ankle international, 34(1), 85-90 (2013-02-07)
The objective of the present study was to explore the effects of deficiencies in glucose regulation on the onset, regression, and block performance times in a group of patients with diabetes-related foot problems. Forty-eight patients with American Society of Anesthetists
P K Gupta et al.
British journal of anaesthesia, 110(5), 831-836 (2013-02-09)
Our aim was to estimate the ED95 of prilocaine 1% w/v for femoral nerve block. This two-stage dose-finding sequential clinical trial followed an adaptive design based on the continual reassessment method (CRM). Adult patients undergoing Vastus medialis muscle biopsy under
Stephanie C J Keating et al.
PloS one, 7(9), e44437-e44437 (2012-09-13)
Ear tattooing is a routine procedure performed on laboratory, commercial and companion rabbits for the purpose of identification. Although this procedure is potentially painful, it is usually performed without the provision of analgesia, so compromising animal welfare. Furthermore, current means
Marco Bragagni et al.
International journal of pharmaceutics, 441(1-2), 468-475 (2012-11-21)
The use of injectable local anaesthetics for the treatment of severe postoperative pain is limited by the short duration of the painkilling effect. Pre-formulation studies were carried out for the development of an injectable microparticle formulation for controlled release of
Brett J Wong
American journal of physiology. Regulatory, integrative and comparative physiology, 304(8), R651-R656 (2013-02-15)
We tested the hypothesis that inhibition of cutaneous sensory nerves would attenuate reflex cutaneous vasodilation in response to an increase in core temperature. Nine subjects were equipped with four microdialysis fibers on the forearm. Two sites were treated with topical
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