G5017
Glycophorin Predominantly glycophorin A from blood type MN
lyophilized powder
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Recommended Products
biological source
human blood (type MN)
Quality Level
form
lyophilized powder
solubility
soluble 1.00-1.10 mg/mL
H2O: soluble, clear to hazy
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... GYPA(2993)
General description
Glycophorin (GYPA), a sialoglycoprotein, is present in human erythrocytes that carry antigens M and N of the MN blood group. The GYPA gene is mapped to human chromosome 4q31.21.
Glycophorin A cconsists of a glycosylated extracellular domain, a single transmembrane α-helix and a cytoplasmic COOH-terminal domain.
Application
Glycophorin A (GpA) is used as a model system for extensive experimental, theoretical, and simulation studies focusing on TM protein association. Glycophorin A is used to study the mechanism of kinase activation in the receptor for colony-stimulating factor 1. It is used to analyse glycoproteins separated by two-dimensional gel electrophoresis.
Glycophorin Predominantly glycophorin A from blood type MN has been used:
- as a standard in Amide-80 column size-based separation for the characterization of plasma-type O-linked sugar chains
- to screen the P. falciparum phage library using biopanning method,
- as a phosphocholine-free component to test its reactivity with antibodies over a saccharide-bound enzyme-linked immunosorbent assay (ELISA)
Biochem/physiol Actions
Glycophorin (GYPA) is involved in the mode of entry of the Plasmodium falciparum parasite into erythrocytes. It is also implicated in intraplaque hemorrhage as well as in the macrophage infiltration in coronary atheromas.
A membrane glycoprotein with several isoforms that interact with other membrane proteins to confer shape and antigenicity to erythrocytes.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
S Raffy et al.
The Journal of biological chemistry, 272(41), 25524-25530 (1997-11-05)
Previously we demonstrated that transmembrane back insertion of glycophorin A, a solubilizable intrinsic protein, can be obtained in dipalmitoylphosphatidylcholine multilamellar vesicles, MLVs, by electropulsation (Raffy, S., and Teissié, J. (1995) Eur. J. Biochem. 230, 722-732). Here we report that transmembrane
C J Pan
Zhonghua bing li xue za zhi = Chinese journal of pathology, 21(4), 224-226 (1992-08-01)
Eighteen cases of anaplastic meningioma were studied by LM, EM and immunohistochemistry for vimentin, EMA, keratin, GFAP and S-100. Microscopically, there were four histologic types, i.e. fibrosarcoma-like, angiosarcoma-like, polymorphic giant cell sarcoma-like and angiopapillary structure. By EM, four kinds of
Samuel C Wassmer et al.
Trends in parasitology, 32(1), 5-7 (2015-11-29)
In Malaŵi, Malungo alibe odi is a saying that translates as: 'Malaria does not ask permission before coming in'. The recent finding of a new severe malaria resistance locus next to a cluster of glycophorin genes involved in Plasmodium falciparum
Alba Fernández-Sánchez et al.
Immunology letters, 123(2), 125-131 (2009-05-12)
The immunization of BALB/c mice with heat-killed cells of Streptococcus mitis SK598 allowed the rescue of mouse monoclonal antibodies (mAbs) reactive with the pneumococcal cell wall C-polysaccharide backbone. We report for the first time the genetic and molecular characterization of
Hajime Mizukami et al.
Journal of human genetics, 50(12), 667-670 (2005-10-06)
Ten alleles (five M and five N alleles) of the MN blood group system with normal antigenicity were found by sequencing the glycophorin A (GPA) gene. This study demonstrates the systematic classification of these alleles to major or minor variations
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service