E7138

Ethosuximide

• Synonym(s): 2-Ethyl-2-methylsuccinimide
• Empirical Formula (Hill Notation): C₇H₁₁NO₂
• CAS Number: 77-67-8
• Molecular Weight: 141.17
• EC Number: 201-048-7
• MDL number: MFCD00072123
• UNSPSC Code: 12352111
• PubChem Substance ID: 24278423
• NACRES: NA.77

Properties

• Quality Level: 100
• solubility: ethanol: 100 mg/mL
• SMILES string: O=C1NC(CC1(C)CC)=O
• InChI: 1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
• InChI key: HAPOVYFOVVWLRS-UHFFFAOYSA-N
• Gene Information: human ... CACNA1G(8913) , CACNA1H(8912) , CACNA1I(8911)

Description

Application

Ethosuximide has been used:

• to confirm its effect on spike wave discharges (SWD) in rats
• to examine its effects on spontaneous locomotion and anxiety-related thigmotaxis behaviours in zebrafish larvae of wild type
• as a model drug for the treatment of epilepsy in vivo(4)

Biochem/physiol Actions

Ethosuximide is an anticonvulsant drug and an antagonist for T-type calcium channel. It is known to prevent spike wave discharges, characterized in absence seizures.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves