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Sigma-Aldrich

Arsenic(III) oxide

ACS reagent (primary standard)

Synonym(s):

Arsenic trioxide, Arsenous acid

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About This Item

Empirical Formula (Hill Notation):
As2O3
CAS Number:
1327-53-3
Molecular Weight:
197.84
EC Number:
215-481-4
MDL number:
MFCD00003433
UNSPSC Code:
12171602
PubChem Substance ID:
329753664
NACRES:
NB.24

grade

ACS reagent (primary standard)

Quality Level

200

vapor pressure

0 hPa ( 66 °C)

Assay

99.95-100.05%

form

powder

reaction suitability

reagent type: catalyst
core: arsenic

ign. residue

≤0.02%

solubility

dilute HCl: insoluble ≤0.01%

anion traces

S2-: passes test (lim. ~0.001%)
chloride (Cl-): ≤0.005%

cation traces

Fe: ≤5 ppm
Pb: ≤0.002%
Sb: ≤0.05%

SMILES string

O=[As]O[As]=O

InChI

1S/As2O3/c3-1-5-2-4

InChI key

IKWTVSLWAPBBKU-UHFFFAOYSA-N

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General description

Arsenic (III) oxide, also referred to as arsenic trioxide, is an amphoteric oxide that is used as a raw material to produce several arsenic-based compounds.

Application

Arsenic (III) oxide is used
  • In the synthesis of arsenic pentafluoride (AsF5) by static fluorination method in a closed system.
  • In the preparation of arsenic-doped ZnO films by adding As2O3 to zinc acetate, 2-methoxyethanol, and monoethanolamine by sol-gel spin coating method.

Signal Word

Danger

Hazard Statements

H300,H314,H350,H372,H410

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Skin Corr. 1B - STOT RE 1

Target Organs

Respiratory system,Cardio-vascular system,Gastrointestinal tract

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Xiao Liu et al.
Science China. Life sciences, 63(11), 1744-1754 (2020-05-10)
This study aimed to explore macrophage polarization in acute graft-versus-host disease after hematopoietic stem cell transplantation, and investigated if arsenic trioxide (ATO) could correct this imbalance. In the colon of GVHD mice, we found that the number of F4/80+iNOS+ cells
Shaohong Fang et al.
Cell death & disease, 12(1), 88-88 (2021-01-20)
Inducing autophagy and inhibiting apoptosis may provide a therapeutic treatment for atherosclerosis (AS). For the treatment of progressive AS, arsenic trioxide (ATO) has been used to coat vascular stents. However, the effect of ATO on autophagy of macrophages is still
Athena Kritharis et al.
Annals of hematology, 92(6), 719-730 (2013-03-16)
For more than 2,000 years, arsenic and its derivatives have shown medical utility. Owing to the toxicities and potential carcinogenicity of arsenicals, their popularity has fluctuated. The exact mechanism of action of therapeutic arsenic is not well characterized but likely
Huihui Wang et al.
Environmental toxicology, 28(5), 267-275 (2013-04-17)
Although arsenic is effective in the treatment of acute promyelocytic leukemia (APL), as a well-known environmental toxicant, the side effects of arsenic treatment and arsenic methylation metabolism of the patients are rarely reported. In this manuscript, we investigated 23 APL
Hong Li et al.
Croatian medical journal, 54(1), 12-16 (2013-02-28)
To investigate the role of tumor apoptosis-inhibitory protein survivin in arsenic trioxide-induced apoptosis in VX-2 carcinoma in the rabbit liver by means of transcatheter arterial chemoembolization. Sixteen rabbits with 32 implanted hepatic VX-2 tumors were randomly divided into two groups.
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