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Y0000022

Sumatriptan succinate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate, GR-43175

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About This Item

Empirical Formula (Hill Notation):
C14H21N3O2S · C4H6O4
CAS Number:
103628-48-4
Molecular Weight:
413.49
MDL number:
MFCD00902856
UNSPSC Code:
41116107
PubChem Substance ID:
329830818
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

sumatriptan

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

OC(=O)CCC(O)=O.CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1

InChI

1S/C14H21N3O2S.C4H6O4/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3;5-3(6)1-2-4(7)8/h4-5,8-9,15-16H,6-7,10H2,1-3H3;1-2H2,(H,5,6)(H,7,8)

InChI key

PORMUFZNYQJOEI-UHFFFAOYSA-N

Gene Information

human ... HTR1B(3351) , HTR1D(3352)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Sumatriptan succinate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Sumatriptan succinate is a 5-HT1 serotonin receptor agonist.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

1642201

Sumatriptan succinate, United States Pharmacopeia (USP) Reference Standard

1642212

Sumatriptan Succinate Related Compound A, United States Pharmacopeia (USP) Reference Standard

Y0000026

Sumatriptan impurity mixture, European Pharmacopoeia (EP) Reference Standard

Y0000027

Sumatriptan for system suitability, European Pharmacopoeia (EP) Reference Standard

1642154

Sumatriptan, United States Pharmacopeia (USP) Reference Standard

1642256

Sumatriptan succinate Related Impurities, United States Pharmacopeia (USP) Reference Standard

1642223

Sumatriptan succinate Related Compound C, United States Pharmacopeia (USP) Reference Standard

BP950

Sumatriptan succinate, British Pharmacopoeia (BP) Reference Standard

PHR2580

Sumatriptan Succinate, pharmaceutical secondary standard, certified reference material

PHR2914

Sumatriptan Succinate Related Compound C, certified reference material, pharmaceutical secondary standard

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H361d,H412

Hazard Classifications

Aquatic Chronic 3 - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Toshihiko Tomita et al.
Journal of gastroenterology and hepatology, 28(1), 106-111 (2012-09-20)
Scintigraphy is a useful noninvasive technique for assessment of gastric motility, especially emptying, but there is little knowledge of use of the technique to assess gastric accommodation. Therefore, to clarify the usefulness of scintigraphy as a technique for assessing gastric
Christian Asseburg et al.
International journal of technology assessment in health care, 28(4), 382-389 (2012-09-28)
The cost-effectiveness of triptans in the treatment of migraine has not been assessed since generic sumatriptan entered the Finnish market in 2008. Using systematic review and mixed treatment comparison, the effectiveness of triptans was estimated with regard to 2-hour response
Daxesh P Patel et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 902, 122-131 (2012-07-24)
An ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed for the simultaneous determination of sumatriptan and naproxen in human plasma using naratriptan and indomethacin as the internal standards (ISs). The plasma samples were prepared by solid phase
Mohammad Sohail Asghar
Danish medical journal, 59(7), B4489-B4489 (2012-07-05)
Over the last decades MRI has proved to be very useful in the field of drug development and drug discovery. Pharmacological MRI (phMRI) explores the interaction between brain physiology, neuronal activity and drugs. The BOLD signal is an indirect method
Nahid Shahabadi et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 99, 18-22 (2012-10-09)
The interaction of native calf thymus DNA with sumatriptan(1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide) at physiological pH was studied by spectrophotometry, circular dichroism, voltammetry and viscosimetric techniques. Sumatriptan molecule intercalated between base pairs of DNA, showed by a sharp increase in specific viscosity of DNA.
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