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463442

Sigma-Aldrich

5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide

95%

Synonym(s):

4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonamide

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About This Item

Linear Formula:
ClC6H3(OCH3)CONHCH2C6H4SO2NH2
CAS Number:
16673-34-0
Molecular Weight:
368.84
EC Number:
240-722-5
MDL number:
MFCD00193756
UNSPSC Code:
12352100
PubChem Substance ID:
24870067
NACRES:
NA.22

Quality Level

100

Assay

95%

mp

209-214 °C (lit.)

SMILES string

COc1ccc(Cl)cc1C(=O)NCCc2ccc(cc2)S(N)(=O)=O

InChI

1S/C16H17ClN2O4S/c1-23-15-7-4-12(17)10-14(15)16(20)19-9-8-11-2-5-13(6-3-11)24(18,21)22/h2-7,10H,8-9H2,1H3,(H,19,20)(H2,18,21,22)

InChI key

KVWWTCSJLGHLRM-UHFFFAOYSA-N

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General description

5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide is an organic building block. It has been reported as an intermediate in the synthesis of glyburide. Synthesis of 5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide has been reported.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Reply to Letter Regarding Article," NLRP3 Inflammasome as a Therapeutic Target in Myocardial Infarction.
Takahashi M.
International Heart Journal, 55(4), 380-380 (2014)
Molecular regulation of cell fate in cerebral ischemia: role of the inflammasome and connected pathways
Trendelenburg G.
Journal of Cerebral Blood Flow and Metabolism (2014)
Carlo Marchetti et al.
Journal of cardiovascular pharmacology, 63(4), 316-322 (2013-12-18)
The formation of the NLRP3 inflammasome in the heart during acute myocardial infarction amplifies the inflammatory response and mediates further damage. Glyburide has NLRP3 inhibitory activity in vitro but requires very high doses in vivo, associated with hypoglycemia. The aim

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