SML0440

Spautin-1

≥98% (HPLC), Autophagy inhibitor, powder

• Synonym(s): 6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine, C43
• Empirical Formula (Hill Notation): C₁₅H₁₁F₂N₃
• CAS Number: 1262888-28-7
• Molecular Weight: 271.26
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824722
• NACRES: NA.77
• MDL number: MFCD16962292
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Spautin-1, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 15 mg/mL (clear solution)
• storage temp.: 2-8°C
• SMILES string: FC1=CC=C(C=C1)CNC2=C3C=C(F)C=CC3=NC=N2
• InChI: 1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
• InChI key: AWIVHRPYFSSVOG-UHFFFAOYSA-N

Description

Application

Spautin-1 has been used as an autophagy inhibitor:

• to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse model[1]
• to evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicin[2]
• to study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay[3]

Biochem/physiol Actions

Spautin-1 inhibits the activity of two ubiquitin-specific peptidases, USP10 and USP13, causing an increase in proteasomal degradation of class III PI3 kinase complexes, which have been shown to regulate autophagy.

Spautin-1 is an inhibitor of autophagy.

Specific and potent autophagy inhibitor-1 (Spautin-1) is a small molecule, which can inhibit autophagy and induce cancer cell death. It inhibits autophagy by degrading beclin-1. Spautin-1 augments the efficiency of radiation therapy and chemotherapy in various human cancer cell lines.[2]

Safety Information

• pictograms: GHS05,GHS07
• signalword: Danger
• hcodes: H302,H318
• pcodes: P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable