SML0136

TGN-020

≥98% (HPLC), AQP4 inhibitor, powder

• Synonym(s): 2-(Nicotinamide)-1,3,4-thiadiazole, N-(1,3,4-Thiadiazol-2-yl)-3-pyridinecarboxamide, N-(1,3,4-Thiadiazol-2-yl)pyridine-3-carboxamide, N-(1,3,4-Thiadiazolyl)-m-nicotinamide
• Empirical Formula (Hill Notation): C₈H₆N₄OS
• CAS Number: 51987-99-6
• Molecular Weight: 206.22
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825185
• NACRES: NA.77
• MDL number: MFCD00708771
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: TGN-020, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥8 mg/mL
• storage temp.: room temp
• SMILES string: O=C(Nc1nncs1)c2cccnc2
• InChI: 1S/C8H6N4OS/c13-7(6-2-1-3-9-4-6)11-8-12-10-5-14-8/h1-5H,(H,11,12,13)
• InChI key: AGEGZHOPKZFKBP-UHFFFAOYSA-N

Description

Application

Beas2B human lung epithelial cells were treated with TGN-020 to study the effect on cigarette smoke extracts-induced CCN1 secretion.

Biochem/physiol Actions

Aquaporin 4 (AQP4) inhibitor

TGN-020 is an inhibitor of Aquaporin 4 (AQP4), the most abundant water channel in brain. Aquaporins (AQPs) are water channels required for maintaining fluid homeostasis and enabling water movement across barrier membranes, but can enhance pathological cellular volume changes and cause edema in injury states. Pretreatment with the AQP4 inhibitor TGN-020 significantly reduced the volume of brain edema associated with ischemic injury in a mouse model of focal cerebral ischemia.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable