P0359

Palmitoylethanolamide

≥98% (HPLC), powder, cannabinoid receptor agonist

• Synonym(s): N-(2-Hydroxyethyl)hexadecanamide, PEA, Palmidrol
• Empirical Formula (Hill Notation): C₁₈H₃₇NO₂
• CAS Number: 544-31-0
• Molecular Weight: 299.49
• NACRES: NA.77
• PubChem Substance ID: 24278619
• UNSPSC Code: 12352200
• EC Number: 208-867-9
• MDL number: MFCD00020562
• Form: powder

Properties

• Product Name: Palmitoylethanolamide,
• form: powder
• Quality Segment: 200
• storage temp.: −20°C
• SMILES string: CCCCCCCCCCCCCCCC(=O)NCCO
• InChI: 1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21)
• InChI key: HXYVTAGFYLMHSO-UHFFFAOYSA-N
• Gene Information: human ... CNR1(1268), CNR2(1269) ; rat ... Faah(29347)

Description

Application

Palmitoylethanolamide has been used as a reference standard in mass spectrometry (MS/MS).[1]

Biochem/physiol Actions

Palmitoylethanolamide (PEA) is a natural fatty acid[2] amide of ethanolamine and palmitic acid.[3] It is found in soybeans, egg yolk, and many other food sources.[4] PEA is an endogenous cannabinoid receptor agonist.[5] It is a peroxisome proliferator-activated receptor α (PPAR-α) ligand. PEA possesses anti-inflammatory, anti-allergic[4], neuroprotective, and analgesic activities.[6] It belongs to the class of lipid mediators and the N-acylethanolamine family. PEA blocks the release of pro-inflammatory mediators from activated mast cells and prevents the recruitment of activated mast cells at the site of nerve injury.[2]

Other Notes

Structural analog of anandamide.

Safety Information

• signalword: Danger
• pictograms: GHS05,GHS09
• hcodes: H315,H318,H411
• pcodes: P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)
• Storage Class: 11 - Combustible Solids