M6760

Myricetin

≥96.0%, crystalline

• Synonym(s): 3,3′,4′,5,5′,7-Hexahydroxyflavone, Cannabiscetin, Myricetol
• Empirical Formula (Hill Notation): C₁₅H₁₀O₈
• CAS Number: 529-44-2
• Molecular Weight: 318.24
• Beilstein: 332331
• EC Number: 208-463-2
• MDL number: MFCD00006827
• UNSPSC Code: 12352202
• PubChem Substance ID: 24278566
• NACRES: NA.77

Properties

• Assay: ≥96.0%
• form: crystalline
• mp: >300 °C (lit.)
• solubility: absolute ethanol: 10 mg/mL, clear to slightly hazy, yellow to very deep greenish-yellow
• SMILES string: Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3cc(O)c(O)c(O)c3
• InChI: 1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
• InChI key: IKMDFBPHZNJCSN-UHFFFAOYSA-N
• Gene Information: human ... CYP1A2(1544) ; mouse ... Hexa(15211) ; rat ... Il4(287287) , Tnf(24835)

Description

Application

Myricetin has been used:

• to investigate its effect on end product (AGE)- bovine serum albumin mediated phosphorylation of mitogen-activated protein kinase(ERK1)
• as a standard for the quantification of phenolics from noni plant extracts using high performance liquid chromatography(HPLC)
• as a standard for characterization of phenolic compounds from Hibiscus sabdariffa using ultra-high performance liquid chromatography(UHPLC)

Biochem/physiol Actions

Myricetin is a naturally occurring flavonol with antioxidant property. It displays moderate membrane permeability and it degrades rapidly at elevated pH. Myricetin is one of the major flavonoid present in edible plants and has anticarcinogenic and antimutagenic functionality. It comprises of two benzene rings A and B. Ring B intercalates with nucleotide staking and inhibits bacterial DNA synthesis. Myricetin elicits protective function against oxidative stress generated by tert-butylhydroperoxide (t-BHP) in diabetic rat and improves glutathione peroxidase (GPx) and xanthine oxidase (XO) enzyme activity. It also lowers the glycation of low-density lipoprotein.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves