L0879
Leu-Leu-Leu
≥90% (elemental analysis), suitable for mass spectrometry (MS)
Synonym(s):
Trileucine
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About This Item
Empirical Formula (Hill Notation):
C18H35N3O4
CAS Number:
Molecular Weight:
357.49
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.26
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Product Name
Leu-Leu-Leu, ≥90% (elemental analysis)
Assay
≥90% (elemental analysis)
form
powder
technique(s)
electron microscopy: suitable
mass spectrometry (MS): suitable
color
white
storage temp.
−20°C
SMILES string
CC(C)CC(N)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(O)=O
InChI
1S/C18H35N3O4/c1-10(2)7-13(19)16(22)20-14(8-11(3)4)17(23)21-15(18(24)25)9-12(5)6/h10-15H,7-9,19H2,1-6H3,(H,20,22)(H,21,23)(H,24,25)
InChI key
DNDWZFHLZVYOGF-UHFFFAOYSA-N
Amino Acid Sequence
Leu-Leu-Leu
Application
Trileucine (Leu-Leu-Leu), an endosome escape moiety, may be used for pH-dependent endosomal membrane disruption to release agents such as antisense oligonucleotides (AONs) inside cells. Trileucine is used to evaluate the absorption characteristics of reversed phase liquid chromatography (HPLC) media.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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S A Adibi et al.
Metabolism: clinical and experimental, 32(2), 103-105 (1983-02-01)
When baboons, while consuming an adequate diet, were infused continuously for 3 days with parenteral solutions (1I/day) containing either triglycine (50 mM) or trileucine (5 mM) there was either no or very little accumulation of these peptides either in plasma
David Lechuga-Ballesteros et al.
Journal of pharmaceutical sciences, 97(1), 287-302 (2007-09-08)
For particles to be useful medicinal aerosols, not only their aerodynamic diameter has to be on the order of a few micrometers but also they have to be chemically and physically stable. Manufacture of respirable particles is a technical challenge
S Yamasaki et al.
Annals of the rheumatic diseases, 60(7), 678-684 (2001-06-19)
To examine whether inhibition of NF-kappaB induces apoptosis of human synovial cells stimulated by tumour necrosis factor alpha (TNFalpha), interleukin 1beta (IL1beta), and anti-Fas monoclonal antibody (mAb). The expression of proliferating cell nuclear antigen (PCNA), NF-kappaB, and the presence of
M Conconi et al.
The Biochemical journal, 333 ( Pt 2), 407-415 (1998-07-11)
Heat-shock protein 90 (Hsp 90) has been implicated in both protection against oxidative inactivation and inhibition of the multicatalytic proteinase (MCP, also known as 20 S proteasome). We report here that the protective and inhibitory effects of Hsp 90 depend
K Go et al.
Biopolymers, 36(5), 607-614 (1995-11-01)
In order to test the helical preference of short oligo-L-leucines, we crystallized the tripeptide L-leucyl-L-leucyl-L-leucine (LLL) and carried out x-ray diffraction studies of it (L-leucyl-L-leucyl-Lleucine)2. 3CH3OH. H2O, (C39H84N6O12), crystallized in the monoclinic system, space group P2(1), cell parameters: a =
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