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Key Documents

HPA029038

Sigma-Aldrich

Anti-CARMIL1 antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, ab1

Synonym(s):

CARMIL, DJ501N12.1, FLJ20048, LRRC16, LRRC16A

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About This Item

UNSPSC Code:
12352203
Human Protein Atlas Number:
NACRES:
NA.43

Pricing and availability is not currently available.

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

independent
orthogonal RNAseq
Learn more about Antibody Enhanced Validation

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1 of 4

This Item
GF09207121GF70390526GF63314827
assay

99.95%

assay

≥99.95%

assay

99.95%

assay

99.95%

manufacturer/tradename

Goodfellow 406-377-52

manufacturer/tradename

Goodfellow 092-071-21

manufacturer/tradename

Goodfellow 703-905-26

manufacturer/tradename

Goodfellow 633-148-27

bp

2567 °C (lit.)

bp

2567 °C (lit.)

bp

2567 °C (lit.)

bp

2567 °C (lit.)

density

8.94 g/mL at 25 °C (lit.)

density

8.94 g/mL at 25 °C (lit.)

density

8.94 g/mL at 25 °C (lit.)

density

8.94 g/mL at 25 °C (lit.)

resistivity

1.673 μΩ-cm, 20°C

resistivity

1.673 μΩ-cm, 20°C

resistivity

1.673 μΩ-cm, 20°C

resistivity

1.673 μΩ-cm, 20°C

General description

LRRC16A (leucine-rich repeat-containing 16A) codes for a capping protein ARP2/3 and myosin-I linker (CARMIL). CARMIL is a big protein, that is expressed in high levels in kidney and other epithelial tissues.

Immunogen

capping protein regulator and myosin 1 linker 1 recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

Biochem/physiol Actions

Protein product of LRRC16A (leucine-rich repeat-containing 16A) plays a major role in cell-shape changes and motility and it also acts as an inhibitor of the actin capping protein (CP). It plays a vital role in ARDS (acute respiratory distress syndrome) risk mediating through platelet count. It also plays an important role in platelet formation. Mutation of this gene may leads to the dysfunction of CARMIL to dislodge the capping protein from the actin filament.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST77297

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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This is a sample Certificate of Analysis (COA) and may not represent a recently manufactured lot of this specific product.

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Common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility
Sakiyama M, et al.
Human Cell : Official Journal of Human Cell Research Society, 27(1), 1-4 (2014)
Platelet count mediates the contribution of a genetic variant in LRRC16A to ARDS risk
Wei Y, et al.
Chest, 147(3), 607-617 (2015)

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