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Key Documents

G5894

Sigma-Aldrich

Glutaminase from Escherichia coli

Grade VII, lyophilized powder, 500-1,500 units/mg protein

Synonym(s):

L-Glutamine amidohydrolase

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About This Item

CAS Number:
Enzyme Commission number:
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54

type

Grade VII

Quality Level

form

lyophilized powder

specific activity

500-1,500 units/mg protein

composition

Protein, ~10% Lowry

storage temp.

−20°C

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Biochem/physiol Actions

Glutaminase catalyzes the conversion of glutamine to glutamate.

Linkage

Chromatographically purified from Grade V

Unit Definition

One unit will deaminate 1.0 μmole of L-glutamine per min at pH 4.9 at 37 °C.

Physical form

Lyophilized powder containing stabilizer and potassium succinate

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Felix List et al.
Chemistry & biology, 19(12), 1589-1599 (2012-12-25)
Nitrogen is incorporated into various metabolites by multifunctional glutamine amidotransferases via reactive ammonia generated by glutaminase hydrolysis of glutamine. Although this process is generally tightly regulated by subsequent synthase activity, little is known about how the glutaminase is inhibited in
Catherine Qiurong Pan et al.
FEBS letters, 586(17), 2674-2691 (2012-06-20)
The BNIP-2 and Cdc42GAP Homology (BCH) domains constitute a new and expanding family of highly conserved scaffold protein domains that regulate Rho, Ras and MAPK signaling, leading to cell growth, apoptosis, morphogenesis, migration and differentiation. Such versatility is achieved via
N V Zharkova et al.
Biomeditsinskaia khimiia, 58(2), 220-223 (2012-06-26)
Acute alcohol intoxication in rats with alloxan diabetes is accompanied by the increase of urea and uric acid and by the decrease in free fatty acids in serum. In the liver of experimental animals the increase of activity of glutamate
Natalie E Simpson et al.
Epigenetics, 7(12), 1413-1420 (2012-11-03)
The interplay of metabolism and epigenetic regulatory mechanisms has become a focal point for a better understanding of cancer development and progression. In this study, we have acquired data supporting previous observations that demonstrate glutamine metabolism affects histone modifications in
Krupa Shukla et al.
Journal of medicinal chemistry, 55(23), 10551-10563 (2012-11-16)
Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) is a potent and selective allosteric inhibitor of kidney-type glutaminase (GLS) that has served as a molecular probe to determine the therapeutic potential of GLS inhibition. In an attempt to identify more potent GLS inhibitors with improved

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