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3,4-Dichloroisocoumarin

Name: 3,4-Dichloroisocoumarin
Brand: SIGMA

≥98% (TLC), Serine protease inhibitor, powder

Synonym(s):

3,4-DCI, 3,4-Dichloro-2-benzopyran-1-one

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About This Item

Empirical Formula (Hill Notation):

C₉H₄Cl₂O₂

CAS Number:

51050-59-0

Molecular Weight:

215.03

NACRES:

NA.77

PubChem Substance ID:

24278386

UNSPSC Code:

12352202

MDL number:

MFCD00036960

Beilstein/REAXYS Number:

6802625

Pricing and availability is not currently available.

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Properties

Product Name

3,4-Dichloroisocoumarin, serine protease inhibitor

Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

ethyl acetate: 49.00-51.00 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

ClC1=C(Cl)c2ccccc2C(=O)O1

InChI

1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H

InChI key

SUGXUUGGLDCZKB-UHFFFAOYSA-N

Description

General description

Serine protease inhibitor. Active towards a wide range of serine proteases including granzymes. Not active toward β-lactamases.

Application

Useful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors.[1]

Preparation Note

Half-life = 20 min at pH 7.5.

Other Notes

Effective concentration 5-100 μM.

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This Item	E1379	SML3559	D104809
Sigma-Aldrich D7910 3,4-Dichloroisocoumarin	Sigma-Aldrich E1379 7-Ethoxycoumarin	Sigma-Aldrich SML3559 LAU-0901	Sigma-Aldrich D104809 Dihydrocoumarin
assay ≥98% (TLC)	assay ≥99.45% (HPLC)	assay ≥98% (HPLC)	assay 99%
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
form powder	form powder	form powder	form liquid
storage temp. 2-8°C	storage temp. -	storage temp. 2-8°C	storage temp. -
solubility ethyl acetate: 49.00-51.00 mg/mL, clear, colorless to faintly yellow	solubility 95% ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow	solubility DMSO: 2 mg/mL, clear	solubility -

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pictograms

GHS06

signalword

Danger

hcodes

H301,H315,H319,H335

pcodes

P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number

0000477754

0000420474

0000301459

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Granzyme B Attenuates Bacterial Virulence by Targeting Secreted Factors.

Diego López León et al.

iScience, 23(3), 100932-100932 (2020-03-11)

Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to contribute crucially to antibacterial defense. Here we show

Cardiovascular and inflammatory mechanisms in healthy humans exposed to air pollution in the vicinity of a steel mill.

Premkumari Kumarathasan et al.

Particle and fibre toxicology, 15(1), 34-34 (2018-08-12)

There is a paucity of mechanistic information that is central to the understanding of the adverse health effects of source emission exposures. To identify source emission-related effects, blood and saliva samples from healthy volunteers who spent five days near a

General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases.

Anežka Tichá et al.

Cell chemical biology, 24(12), 1523-1536 (2017-11-07)

Rhomboid-family intramembrane proteases regulate important biological processes and have been associated with malaria, cancer, and Parkinson's disease. However, due to the lack of potent, selective, and pharmacologically compliant inhibitors, the wide therapeutic potential of rhomboids is currently untapped. Here, we

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Global Trade Item Number

SKU	GTIN
D7910-10MG	04061833270547
D7910-5MG	04061833270561
D7910-25MG	04061833270554

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