This product is not sterile. Prepared solutions may be filter sterilized.
D0627
N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt
N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt
≥96% (HPLC), powder
Synonym(s):
Bucladesine sodium salt, Dibutyryl cAMP sodium salt, Dibutyryl cyclic-AMP sodium salt
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About This Item
Linear Formula:
C18H23N5O8PNa
CAS Number:
Molecular Weight:
491.37
EC Number:
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
Pricing and availability is not currently available.
Recommended Products
biological source
synthetic (organic)
Assay
≥96% (HPLC)
form
powder
impurities
≤0.5% Cyclic AMP
≤3% monobutyryl derivatives
color
off-white
solubility
H2O: 100 mg/mL
storage temp.
−20°C
SMILES string
[Na+].CCCC(=O)Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3OC(=O)CCC
InChI
1S/C18H24N5O8P.Na/c1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14;/h8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24);/q;+1/p-1/t10-,14-,15-,18-;/m1./s1
InChI key
KRBZRVBLIUDQNG-JBVYASIDSA-M
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Application
Dibutyryl CAMP is a cell-permeable CAMP analogue that activates CAMP dependent protein kinase (PKA) or the CAMP/PKA signaling pathway. Dibutyryl CAMP is used as a morphological differentiation inducer and cell signaling modulator in cells such as Schwann cells. Dibutyrl cAMP is used in a variety of differentiation studies, such as neuron differentiation / neuronal differentiation.
Biochem/physiol Actions
Cell-permeable cAMP analog that activates cAMP dependent protein kinase (PKA).
Caution
Loses 2′-O-butyryl group at pH 8.5
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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is this product sterile?
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How long is it stable in -20ºC after reconstitution in DMSO or H2O at 200mM? Do you have any recommendations for stability once the product is in solution?
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This product is soluble in water at 100 mg/mL. The solubility in DMSO has not been determined. Following reconstitution, aliquot and freeze at -20°C for up to 3 months or refrigerate at 2 - 8°C for up to 3 days. Avoid pH of 8.5 or greater as hydrolysis will occur. Please see the link below to review the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/368/353/d0627pis-ms.pdfHelpful?
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