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C5366

Chlorisondamine diiodide

Name: Chlorisondamine diiodide
Brand: SIGMA

≥98% (HPLC), nicotinic acetylcholine receptor antagonist, solid

Synonym(s):

4,5,6,7-Tetrachloro-2,3-dihydro-2-methyl-2-[2-(trimethylammonio)ethyl]-2H-isoindolium diiodide

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₂₀Cl₄I₂N₂

CAS Number:

96750-66-2

Molecular Weight:

611.94

UNSPSC Code:

12352116

PubChem Substance ID:

24724443

NACRES:

NA.77

MDL number:

MFCD01074794

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

protect from light

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Properties

Product Name

Chlorisondamine diiodide, ≥98% (HPLC), white, solid

Quality Segment

200

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

white

solubility

H₂O: ≥2 mg/mL, DMSO: >20 mg/mL

storage temp.

2-8°C

SMILES string

[I-].[I-].C[N+](C)(C)CC[N+]1(C)Cc2c(Cl)c(Cl)c(Cl)c(Cl)c2C1

InChI

1S/C14H20Cl4N2.2HI/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15;;/h5-8H2,1-4H3;2*1H/q+2;;/p-2

InChI key

FPNVAOZHQUJJJQ-UHFFFAOYSA-L

Description

Application

Chlorisondamine diiodide has been used:

as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis
as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction
as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress

Biochem/physiol Actions

Chlorisondamine diiodide mediates ganglionic and central blockade.

Irreversible, long-lasting nicotinic acetylcholine receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.