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C4654
Cytidine
BioReagent, suitable for cell culture, powder, ≥99%
Synonym(s):
Cytosine β-D-riboside, Cytosine-1-β-D-ribofuranoside
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About This Item
Empirical Formula (Hill Notation):
C9H13N3O5
CAS Number:
Molecular Weight:
243.22
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
EC Number:
200-610-9
Beilstein/REAXYS Number:
89173
MDL number:
Assay:
≥99%
Biological source:
synthetic
Form:
powder
Solubility:
H2O: 50 mg/mL
Pricing and availability is not currently available.
biological source
synthetic
Quality Level
product line
BioReagent
assay
≥99%
form
powder
technique(s)
cell culture | mammalian: suitable
mp
210-220 °C (dec.) (lit.)
solubility
H2O: 50 mg/mL
SMILES string
NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
InChI
1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1
InChI key
UHDGCWIWMRVCDJ-XVFCMESISA-N
Gene Information
mouse ... Uck1(22245)
General description
Cytidine is a nucleoside molecule. It is formed when cytosine is attached to a ribose ring through a β-N1-glycosidic bond.[1]
Application
Cytidine has been used as a component to prepare ribonucleoside stock solution to assess its effects on the anaerobic growth of several Bacillus mojavensis strains.[2]
Cytidine has been used as a non-essential aminoacid component of minimal essential medium (MEM) to analyse interspecies somatic cell nucleus transfer (iSCNT)-derived blastocysts. It has also been used as a supplement in the culture medium of HeLa cells, to study the effects of cytidine addition on rods and rings (RR) induced by glutamine deprivation.
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This Item | |||
|---|---|---|---|
| biological source synthetic | biological source - | biological source synthetic (organic) | biological source synthetic (organic) |
| Quality Level 300 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| assay ≥99% | assay 99% | assay ≥99% | assay ≥99% |
| form powder | form powder | form powder | form powder |
| solubility H2O: 50 mg/mL | solubility - | solubility H2O: 50 mg/mL, clear, colorless | solubility H2O: 50 mg/mL |
| mp 210-220 °C (dec.) (lit.) | mp 210-220 °C (dec.) (lit.) | mp 163-167 °C (lit.) | mp 163-167 °C (lit.) |
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Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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G P Gerrits et al.
Clinical chemistry, 34(7), 1439-1442 (1988-07-01)
Disturbances in the metabolism of purines and pyrimidines in neurologically affected patients can be reflected by aberrant concentrations of nucleosides and nucleobases in cerebrospinal fluid (CSF). However, normal values, especially for children at different ages, are lacking. We collected 1000
Leonidas Chouliaras et al.
Neurobiology of aging, 34(9), 2091-2099 (2013-04-16)
Epigenetic dysregulation of gene expression is thought to be critically involved in the pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation and DNA hydroxymethylation are 2 important epigenetic mechanisms that regulate gene expression in the aging brain.
Filippo M Cernilogar et al.
Nucleic acids research, 47(17), 9069-9086 (2019-07-28)
Pioneer transcription factors (PTF) can recognize their binding sites on nucleosomal DNA and trigger chromatin opening for recruitment of other non-pioneer transcription factors. However, critical properties of PTFs are still poorly understood, such as how these transcription factors selectively recognize
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C4654-1G | 04061833492451 |
| C4654-100MG | 04061832305745 |
| C4654-5G | 04061833492475 |
| C4654-50G | 04061833492468 |
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What is the Department of Transportation shipping information for this product?
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How do I dissolve Product No. C4654, Cytidine?
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The product is tested for solubility in water at 50 mg/mL. It may be soluble at higher concentrations as well. Solutions of cytidine are clear or can be faint yellow in color.
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How does the storage temperature relate to shipping conditions?
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The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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