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B9934

BTA-1

Name: BTA-1
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

2-(4´-Methylaminophenyl)benzothiazole

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₂N₂S

CAS Number:

439858-28-3

Molecular Weight:

240.32

NACRES:

NA.77

PubChem Substance ID:

24724428

UNSPSC Code:

12352200

MDL number:

MFCD04974146

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

yellow

solubility

DMSO: soluble ~10 mg/mL

storage temp.

2-8°C

SMILES string

CNc1ccc(cc1)-c2nc3ccccc3s2

InChI

1S/C14H12N2S/c1-15-11-8-6-10(7-9-11)14-16-12-4-2-3-5-13(12)17-14/h2-9,15H,1H3

InChI key

FHJRKGXJBXPBGA-UHFFFAOYSA-N

Gene Information

human ... APP(351)

Description

Biochem/physiol Actions

BTA-1 is a fluorescent thioflavin-T derivative with 50-fold higher affinity for β-amyloid aggregates.

BTA-1 is a probe for β-amyloid aggregates; fluorescent thioflavin-T derivative; exhibits high affinity for amyloid deposits; displays 50-fold higher affinity than thioflavin-T; selectively stains cerebral plaques and cerebrovascular amyloid deposits in the brains of PS1/APP transgenic mice, as well as Aβ fibrils in postmortem brain tissue obtained from AD patients; crosses the blood brain barrier.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse Models.

Ruiqing Ni et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 59(6), 960-966 (2018-02-09)

Fibrillary tau aggregates in Alzheimer disease and allied neurodegenerative disorders have been visualized in vivo by PET, whereas mechanistic links between PET-detectable tau deposits and neurotoxicity remain elusive. Here, we took advantage of transgenic mouse models of tauopathies to evaluate

A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.

Chester A Mathis et al.

Bioorganic & medicinal chemistry letters, 12(3), 295-298 (2002-01-30)

The synthesis of a new lipophilic thioflavin-T analogue (2-[4' -(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [(11)C]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were imaged with multiphoton microscopy in the

Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain.

W E Klunk et al.

Life sciences, 69(13), 1471-1484 (2001-09-14)

In vivo assessment of the beta-sheet proteins deposited in amyloid plaques (A beta peptide) or neurofibrillary tangles (tau protein) presents a target for the development of biological markers for Alzheimer's disease (AD). In an effort to develop in vivo beta-sheet

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Global Trade Item Number

SKU	GTIN
B9934-25MG	04061832977126
B9934-5MG	04061832977133