B6938
Bisdemethoxycurcumin
≥98% (HPLC), NF-kB transcriptional activity inhibitor, solid
Synonym(s):
(1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
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About This Item
Empirical Formula (Hill Notation):
C19H16O4
CAS Number:
Molecular Weight:
308.33
UNSPSC Code:
12352205
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Pricing and availability is not currently available.
Product Name
Bisdemethoxycurcumin, ≥98% (HPLC), solid
Quality Level
assay
≥98% (HPLC)
form
solid
solubility
DMSO: ≥20 mg/mL
storage temp.
2-8°C
SMILES string
Oc1ccc(cc1)\C=C\C(=O)CC(=O)\C=C\c2ccc(O)cc2
InChI
1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+
InChI key
PREBVFJICNPEKM-YDWXAUTNSA-N
Application
Bisdemethoxycurcumin has been used:
- to test its inhibitory effect on cell cycle and mitochondrial function in gastric adenocarcinoma cells[1]
- to test it neuroprotective role against lead (Pb) induced toxicity in dopaminergic and noradrenergic systems of Meriones shawi[2]
- as a standard for calibration curve generation to quantify plasma curcuminoids using high-performance liquid chromatography-diode array detection (HPLC-DAD) and ultraviolet (UV)
Biochem/physiol Actions
Bisdemethoxycurcumin (BDMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. BDMC shares similar anti-inflammatory properties with demethoxycurcumin. It inhibits LPS-induced nitric oxide (NO) production and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. BDMC also displays unique properties in that it enhances Abeta clearance by upregulating expression MGAT3 and TLR genes. BDMC potently inhibits AKR1B10.
Bisdemethoxycurcumin (BMDC) is a stable dimethoxy derivative of curcumin and is useful as a supplement in cell culture medium.[1] It also possesses antimicrobial, antioxidative and neuroprotective functionality.[2]
Inhibitor of NF-kB transcriptional activity
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This Item | |||
|---|---|---|---|
| form solid | form powder | form powder | form - |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥95.0% (HPLC) |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - |
| solubility DMSO: ≥20 mg/mL | solubility DMSO: ≥10 mg/mL | solubility DMSO: 1 mg/mL, clear (warmed) | solubility - |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Lahcen Tamegart et al.
Comptes rendus biologies, 342(5-6), 192-198 (2019-09-03)
Exposure to lead is a threat factor for neurodegenerative disorders progress as it could trigger dopaminergic deficiency. We aimed herein to assess the effect of acute lead exposure (25mg/kg B.W i.p.) during three continuous days on the dopaminergic and noradrenergic
Brazilian Curcuma longa L. attenuates comorbidities by modulating adipose tissue dysfunction in obese rats
Lo ATC, et al.
Nutrire, 43(1), 25-25 (2018)
Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction.
Changjiang Luo et al.
Oncology letters, 9(1), 270-274 (2014-12-02)
Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin. In this study, a human gastric adenocarcinoma xenograft model was generated in vivo using nude mice and BDMC was observed to suppress the growth and activity of tumors, in addition to improving
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B6938-25MG | 04061833438329 |
| B6938-5MG | 04061833441510 |