B5556
Bay 11-7082
≥98% (HPLC), powder, NF-kB/TNF-α inhibitor
Synonym(s):
(E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile
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About This Item
Empirical Formula (Hill Notation):
C10H9NO2S
CAS Number:
Molecular Weight:
207.25
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Product Name
Bay 11-7082, ≥98% (HPLC), powder
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: >20 mg/mL
H2O: insoluble
SMILES string
Cc1ccc(cc1)S(=O)(=O)\C=C\C#N
InChI
1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
InChI key
DOEWDSDBFRHVAP-KRXBUXKQSA-N
Application
Bay 11-7082 has been used as:
- a nuclear factor-kappa B (NF-kB) inhibitor to verify the action of the NF-kB signaling pathway in the production of interleukin (IL)-8
- a nuclear factor-kappa B (NF-kB) inhibitor to study the role of NF-kB activation in Mycoplasma hyorhinis -induced epithelial-mesenchymal transition (EMT) and cell migration
- a nod-like receptor family pyrin domain containing 3 (NLRP3) selective inhibitor to examine its effects on liver inflammation in mice after hematopoietic stem cell transplantation
Biochem/physiol Actions
Bay 11-7082 acts as a selective inhibitor for nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway. In addition, to the inhibition of nuclear factor-kappa B (NF-kB), Bay 11-7082 also triggers apoptosis in anucleated erythrocytes, human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines and primary adult T-cell leukemia cells.
Bay 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Scientific reports, 5, 17828-17828 (2015)
The NFkB pathway inhibitors Bay 11-7082 and parthenolide induce programmed cell death in anucleated Erythrocytes
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The Journal of Biological Chemistry, 285(13), 9792-9802 (2010)
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