87472
Hydrogen chloride solution
~3 M in 1-butanol, for GC derivatization, LiChropur™
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About This Item
CAS Number:
Beilstein:
1098214
MDL number:
UNSPSC Code:
12352301
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
product name
Hydrogen chloride - 1-butanol solution, ~3 M in 1-butanol, for GC derivatization, LiChropur™
grade
for GC derivatization
Quality Level
form
solution
quality
LiChropur™
reaction suitability
reagent type: derivatization reagent
reaction type: Acylations
concentration
~3 M in 1-butanol
technique(s)
gas chromatography (GC): suitable
density
0.87 g/mL at 20 °C
storage temp.
2-8°C
SMILES string
Cl
InChI
1S/ClH/h1H
InChI key
VEXZGXHMUGYJMC-UHFFFAOYSA-N
General description
Acylation, an alternative to silylation, is the conversion of compounds that contain active hydrogens (-OH, -SH and -NH) into esters, thioesters, and amides through the action of a carboxylic acid or derivative. The presence of a carbonyl group adjacent to the halogenated carbons enhances electron capture detector (ECD) response. Acylation has many benefits:
Hydrogen chloride-1-butanol is a reagent utilized to form fragmentation-directing derivatives for GC/MS analysis.
- It improves the stability of compounds by protecting unstable groups.
- It may confer volatility on substances such as carbohydrates or amino acids, which have so many polar groups that they are non-volatile and normally decompose on heating.
- It assists in separations not possible with underivatized compounds.
- Compounds are detectable at very low levels with an ECD.
Hydrogen chloride-1-butanol is a reagent utilized to form fragmentation-directing derivatives for GC/MS analysis.
Application
Hydrogen chloride - 1-butanol solution has been used for butylation of amino acids during blood sample analysis for determination of ethylenediaminetetraacetic acid using mass spectrometry.
Other Notes
Reagent for the esterification of amino acids and carnites for GC-MS analysis
Legal Information
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
3 - Flammable liquids
WGK
WGK 1
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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