A partial, low-potency agonist highly selective for mGlu4 receptors (EC50 >100 µM, no effect on other mGlu subtype receptors). Used in assessing the functional roles of mGlu4 receptors in a variety of research areas, such as excitotoxic cell death, apoptosis, neuroinflammation, inflammation, and neuroimmune communication.
Biochem/physiol Actions
Primary Target mGlu₄ receptors
Warning
Toxicity: Standard Handling (A)
Preparation Note
Slight warming is required for complete solubilization.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Fazio, Francesco, et al. 2012. Mol. Pharmacol.81, 643.
Volpi, C., et al. 2012. Neuropharmacol.63, 501. Hiramatsu, R., et al. 2008. J. Cell Biochem.103, 42.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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