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246573

Sigma-Aldrich

6,7-Dihydroxycoumarin

98%

Synonym(s):

Cichorigenin, Esculetin

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About This Item

Empirical Formula (Hill Notation):
C9H6O4
CAS Number:
Molecular Weight:
178.14
Beilstein:
152788
EC Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23

Assay

98%

form

powder

mp

271-273 °C (lit.)

SMILES string

Oc1cc2OC(=O)C=Cc2cc1O

InChI

1S/C9H6O4/c10-6-3-5-1-2-9(12)13-8(5)4-7(6)11/h1-4,10-11H

InChI key

ILEDWLMCKZNDJK-UHFFFAOYSA-N

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yusuf Erdogdu
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 106, 25-33 (2013-01-29)
In this work, we report a combined experimental and theoretical study on molecular structure, vibrational spectra and electronic properties of Esculetin (ESC). The FT-IR, FT-Raman and FT-NMR spectra have been recorded and analyzed. The molecular geometry, harmonic vibrational frequencies, chemical
Risto O Juvonen et al.
Planta medica, 85(6), 453-464 (2019-02-09)
Scoparone, a major constituent of the Chinese herbal medicine Yin Chen Hao, expresses beneficial effects in experimental models of various diseases. The intrinsic doses and effects of scoparone are dependent on its metabolism, both in humans and animals. We evaluated
Dhamodaran Prabakaran et al.
Biochimie, 95(2), 366-373 (2012-10-20)
Diabetes mellitus is the most common serious metabolic disorder and it is considered to be one of the five leading causes of death in the world. Hyperglycemia-mediated oxidative stress plays a crucial role in diabetic complications. Hence, this study was
Eun-Sun Yun et al.
Toxicology in vitro : an international journal published in association with BIBRA, 25(7), 1335-1342 (2011-05-24)
The phenolic compound esculetin is known to inhibit the proliferation of vascular smooth muscle cells (VSMC). However, the signaling pathway by which esculetin mediates its molecular effects in VSMC remains to be identified. The present results suggest an unexpected role
Sudhakar R Subramaniam et al.
Toxicology and applied pharmacology, 250(2), 130-136 (2010-10-12)
Esculetin (6,7-dihydroxy coumarin), is a potent antioxidant that is present in several plant species. The aim of this study was to investigate the mechanism of protection of esculetin in human hepatoma HepG2 cells against reactive oxygen species (ROS) induced by

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