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Supelco

N-Nitrosodimethylamine (NDMA) solution

certified reference material, 200 μg/mL in methanol

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About This Item

CAS Number:
62-75-9
MDL number:
MFCD00002053
UNSPSC Code:
12000000

grade

certified reference material
TraceCERT®

Quality Level

300

Agency

EPA TO-7

product line

TraceCERT®

CofA

current certificate can be downloaded

feature

standard type calibration

packaging

ampule of 1 mL

concentration

200 μg/mL in methanol

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care

format

single component solution

storage temp.

2-30°C

InChI

1S/C2H6N2O/c1-4(2)3-5/h1-2H3

InChI key

UMFJAHHVKNCGLG-UHFFFAOYSA-N

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General description

N-Nitrosodimethylamine is a toxic type of N-nitrosamine, which can be commonly synthesized in vivo by intestinal microbiota type of microorganisms. It can undergo reduction to form dimethylamine using zero-valent metal ions like Fe and Zn in the presence of Cu(II) ions.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Legal Information

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 1B - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
LRAD9243
LRAD6044
LRAC9929
LRAC5427
LRAC3125

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The role of Cu (II) in the reduction of N-nitrosodimethylamine with iron and zinc
Han Y, et al.
Chemosphere, 167, 171-177 (2017)
Lactic acid bacteria directly degrade N-nitrosodimethylamine and increase the nitrite-scavenging ability in kimchi
Kim H-S, et al.
Food Control, 71, 101-109 (2017)
Jin Woong Kim et al.
Journal of magnetic resonance imaging : JMRI, 53(2), 554-563 (2020-07-03)
Liver fibrosis is characterized by the excessive accumulation of extracellular matrix proteins. Electrical conductivity imaging at low frequency can provide novel contrast because the contrast mechanisms originate from the changes in the concentration and mobility of ions in the extracellular
András P Keszei et al.
The American journal of clinical nutrition, 97(1), 135-146 (2012-11-30)
Dietary N-nitroso compounds and endogenous nitrosation are important carcinogenic factors, but human evidence of their role is scarce for esophageal cancer and inconsistent for gastric cancer. We studied the relation between risks of esophageal and gastric cancer subtypes and dietary
R Sferra et al.
European review for medical and pharmacological sciences, 16(11), 1484-1498 (2012-11-01)
Hepatic fibrosis is characterised by a progressive accumulation of fibrillar extracellular matrix (ECM) proteins, including collagen that occurs in chronic liver diseases. Transforming growth factor-beta1 (TGF-beta)/Smad3 signalling plays a major role in tissue fibrogenesis acting as a potent stimulus of
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