T0951
Anti-Tet Repressor (TETR) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Tetracycline Repressor Protein
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~22 kDa by calculation
species reactivity
human
technique(s)
indirect ELISA: suitable
western blot: 1:1,000
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
Tet Repressor (TETR) is homodimer comprising a C-terminal helix-turn-helix motif (HTH) and N-terminal DNA-binding domain,. It also has a C-terminal tetracycline-binding and dimerization (TBD) domain.
Immunogen
Anti-Tet Repressor (TETR) reacts with amino acid residues 31-49 (AQKLGVEQPTLYWHVKNKR) of 22 kDa Tet repressor protein
Application
Anti-Tet Repressor (TETR) antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
The Tet system is employed in conditional gene expression studies in eukaryotic cells. TetR ( can be used for such applications in some organisms without further modifications. In mammals and in a large variety of other organisms, however, eukaryotic transcriptional activator or repressor domains are fused to TetR to turn it into an efficient regulator. TetR interaction with antibiotic tetracyclin decreases its binding affinity to DNA.
Physical form
Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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The induction of folding cooperativity by ligand binding drives the allosteric response of tetracycline repressor
Reichheld SE, et al.
Proceedings of the National Academy of Sciences of the USA, 106(52), 22263-22268 (2009)
The application of Tet repressor in prokaryotic gene regulation and expression
Bertram R and Hillen W
Microbial Biotechnology, 1(1), 2-16 (2008)
FOXO1 is an essential regulator of pluripotency in human embryonic stem cells
Zhang X, et al.
Nature Cell Biology, 13(9), 1092-1092 (2011)
The TetR family of transcriptional repressors
Ramos JL, et al.
Microbiology and Molecular Biology Reviews, 69(2), 326-356 (2005)
Alicia Broto et al.
Nature communications, 13(1), 1910-1910 (2022-04-09)
Mycoplasmas have exceptionally streamlined genomes and are strongly adapted to their many hosts, which provide them with essential nutrients. Owing to their relative genomic simplicity, Mycoplasmas have been used to develop chassis for biotechnological applications. However, the dearth of robust
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