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Key Documents

SML3251

Sigma-Aldrich

GRL-1720

≥98% (HPLC)

Synonym(s):

1H-Indole-4-carboxylic acid 5-chloro-3-pyridinyl ester, 5-Chloro-3-pyridinyl 1H-indole-4-carboxylate, GRL 0496, GRL-0496, GRL0496

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About This Item

Empirical Formula (Hill Notation):
C14H9ClN2O2
CAS Number:
Molecular Weight:
272.69
MDL number:
UNSPSC Code:
51111800
NACRES:
NA.77

Pricing and availability is not currently available.

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥2 mg/mL, clear

storage temp.

2-8°C

SMILES string

ClC1=CN=CC(OC(C2=CC=CC3=C2C=CN3)=O)=C1

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Show Differences

1 of 4

This Item
SML2705SML3139PZ0319
GRL-1720 ≥98% (HPLC)

SML3251

GRL-1720

TP-008 ≥98% (HPLC)

SML2705

TP-008

ITE ≥98% (HPLC)

SML3139

ITE

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

solubility

DMSO: ≥2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

GRL-1720 is an irreversible, covalent inhibitor of SARS-CoV-2 Mpro that blocks virus replication. GRL-1720 protects VeroE6 cells form SARS-CoV-2WK-521 infection. It shows no significant cytotoxicity to several cell lines.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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    Arun K Ghosh et al.
    Bioorganic & medicinal chemistry letters, 18(20), 5684-5688 (2008-09-18)
    Design, synthesis and biological evaluation of a series of 5-chloropyridine ester-derived severe acute respiratory syndrome-coronavirus chymotrypsin-like protease inhibitors is described. Position of the carboxylate functionality is critical to potency. Inhibitor 10 with a 5-chloropyridinyl ester at position 4 of the
    Marina Macchiagodena et al.
    Journal of chemical theory and computation, 16(11), 7160-7172 (2020-10-23)
    In the context of drug-receptor binding affinity calculations using molecular dynamics techniques, we implemented a combination of Hamiltonian replica exchange (HREM) and a novel nonequilibrium alchemical methodology, called virtual double-system single-box, with increased accuracy, precision, and efficiency with respect to
    Shin-Ichiro Hattori et al.
    Nature communications, 12(1), 668-668 (2021-01-30)
    Except remdesivir, no specific antivirals for SARS-CoV-2 infection are currently available. Here, we characterize two small-molecule-compounds, named GRL-1720 and 5h, containing an indoline and indole moiety, respectively, which target the SARS-CoV-2 main protease (Mpro). We use VeroE6 cell-based assays with

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