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P7943

Sigma-Aldrich

L-α-Phosphatidylethanolamine from egg yolk

Type III, ≥97% (TLC), lyophilized powder

Synonym(s):

1,2-Diacyl-sn-glycero-3-phosphoethanolamine, L-α-Cephalin

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About This Item

CAS Number:
39382-08-6
EC Number:
254-438-4
MDL number:
MFCD00146357
UNSPSC Code:
51191904
NACRES:
NA.25

biological source

egg yolk

Quality Level

200

type

Type III

Assay

≥97% (TLC)

form

lyophilized powder

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

ambient

storage temp.

−20°C

InChI

1S/C40H80NO8P/c1-3-5-7-9-11-13-15-17-18-19-20-21-23-25-27-29-31-33-40(43)49-38(37-48-50(44,45)47-35-34-41)36-46-39(42)32-30-28-26-24-22-16-14-12-10-8-6-4-2/h38H,3-37,41H2,1-2H3,(H,44,45)/t38-/m1/s1

InChI key

NJGIRBISCGPRPF-KXQOOQHDSA-N

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General description

L-α-Phosphatidylethanolamine from egg yolk has high unsaturated fatty acid content and elicits radical-scavenging activity. L-α-Phosphatidylethanolamine (PE) is a membrane phospholipid and is interconverted to phosphotidylserine in the presence of phosphatidylserine synthase 2. PE is essential for maintaining the structural integrity of membranes. It is the second most abundant phospholipid in animals, plants and yeast and the major lipid in bacteria. It is synthesized in mitochondria in mammals.

Application

L-α-Phosphatidylethanolamine from egg yolk has been used:
  • as a component of lipid mixture for the synthesis of giant unilamellar vesicles (GUVs)
  • in ceramide phosphoethanolamine (CPE) synthase assay using crude sphingomyelin synthase-related protein from Hela cells
  • for the standard curve generation for the quantification of lipids in plantaris muscle homogenates from mice

Packaging

Packaged under Argon.

Caution

Purity when prepared is 97-99%. Solutions exposed to room temperature can decompose 0.3-0.5% per day.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Scolopendin 2, a cationic antimicrobial peptide from centipede, and its membrane-active mechanism
Lee H, et al.
Biochimica et Biophysica Acta - Biomembranes, 1848(2), 634-642 (2015)
Egg Yolk Phosphatidylethanolamine: Extraction Optimization, Antioxidative Activity, and Molecular Structure Profiling
Sun N, et al.
Journal of Food Science (2019)
Elevated whole muscle phosphatidylcholine: phosphatidylethanolamine ratio coincides with reduced SERCA activity in murine overloaded plantaris muscles
Fajardo VA, et al.
Lipids in Health and Disease, 17(1), 47-47 (2018)
Tingbo Ding et al.
Journal of lipid research, 56(3), 537-545 (2015-01-22)
Sphingomyelin synthase-related protein (SMSr) synthesizes the sphingomyelin analog ceramide phosphoethanolamine (CPE) in cells. Previous cell studies indicated that SMSr is involved in ceramide homeostasis and is crucial for cell function. To further examine SMSr function in vivo, we generated Smsr
Boris Fichtman et al.
Molecular biology of the cell, 21(23), 4197-4211 (2010-10-12)
Nuclear pore complexes (NPCs) are large proteinaceous channels embedded in double nuclear membranes, which carry out nucleocytoplasmic exchange. The mechanism of nuclear pore assembly involves a unique challenge, as it requires creation of a long-lived membrane-lined channel connecting the inner
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