Skip to Content
Merck
All Photos(1)

Key Documents

L2270

Sigma-Aldrich

Lys-Ala 4-methoxy-β-naphthylamide dihydrochloride

dipeptidylpeptidase II substrate

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C20H28N4O3 · 2HCl
CAS Number:
Molecular Weight:
445.38
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.28

Quality Level

Assay

≥97.5% (TLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless to yellow (and colorless to faint brown and colorless to brown-yellow)

storage temp.

−20°C

SMILES string

Cl.Cl.COc1cc(NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCCN)cc2ccccc12

InChI

1S/C20H28N4O3.2ClH/c1-13(23-20(26)17(22)9-5-6-10-21)19(25)24-15-11-14-7-3-4-8-16(14)18(12-15)27-2;;/h3-4,7-8,11-13,17H,5-6,9-10,21-22H2,1-2H3,(H,23,26)(H,24,25);2*1H/t13-,17-;;/m0../s1

InChI key

GJOOJLYXFGXARX-ZMQOMOPGSA-N

Application

Lys-Ala 4-methoxy-β-naphthylamide dihydrochloride has been used as a substrate to measure the dipeptidyl peptidase II (DPPII) from Vigna radiata seeds.

Substrates

Fluorogenic substrate for dipeptidyl aminopeptidase II.

Pictograms

Health hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Carc. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

R Gossrau et al.
Histochemistry, 70(1), 53-76 (1980-01-01)
The activity of dipeptidylpeptidase II (DPP II; E.C. 3.4.14.2) was investigated by biochemical and histochemical methods in rat, mouse and guinea-pig organs as well as in human enterobiopsies. Lys-Pro-MNA and Ala-Pro-MNA showed the most favorable kinetic properties (Km, Vmax) and
F A Dolbeare et al.
Clinical chemistry, 23(8), 1485-1491 (1977-08-01)
Enzyme activity can be measured in single cells or in cell suspensions by either static or flow microfluorometry when a fluorogenic substrate is used. We have used amino acid derivatives of arylamines as fluorogenic substrates for tagging cellular proteinases. The

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service