H0786
Heregulin-β, EGF Domain human
≥80% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution
Synonym(s):
HRG-β
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About This Item
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biological source
human
Quality Level
recombinant
expressed in E. coli
Assay
≥80% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
185 kDa
packaging
pkg of 100 μg
storage condition
avoid repeated freeze/thaw cycles
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... NRG1(3084)
General description
Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin.
Biochem/physiol Actions
Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.
Physical form
Solution in phosphate buffered saline containing 30% glycerol.
Analysis Note
Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor.
The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Marcia R Campbell et al.
Cell reports, 38(5), 110291-110291 (2022-02-03)
Effective inactivation of the HER2-HER3 tumor driver has remained elusive because of the challenging attributes of the pseudokinase HER3. We report a structure-function study of constitutive HER2-HER3 signaling to identify opportunities for targeting. The allosteric activation of the HER2 kinase
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