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E6527

Sigma-Aldrich

Elastin, soluble from bovine neck ligament

salt-free, lyophilized powder

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About This Item

CAS Number:
9007-58-3
EC Number:
232-701-4
MDL number:
MFCD02687372
UNSPSC Code:
12352202
NACRES:
NA.61

biological source

bovine neck ligament

Quality Level

100

form

salt-free, lyophilized powder

technique(s)

UV/Vis spectroscopy: suitable

UniProt accession no.

P04985

storage temp.

2-8°C

InChI

1S/C27H48N6O6/c1-9-17(6)23(32-24(36)19(13-15(2)3)30-18(7)34)26(38)29-14-21(35)31-22(16(4)5)27(39)33-12-10-11-20(33)25(37)28-8/h15-17,19-20,22-23H,9-14H2,1-8H3,(H,28,37)(H,29,38)(H,30,34)(H,31,35)(H,32,36)/t17-,19-,20-,22-,23-/m0/s1

InChI key

DPUYCSDGMSDKKV-MKBYFEBXSA-N

Gene Information

cow ... ELN(280781)

General description

Water-soluble powder prepared by method of Partrige, et al.

Application

Elastin is a structural protein which has been used in studies of chronic obstructive pulmonary disease (COPD). It may be used to investigate why there is a lack of repair for these proteins in patients with COPD.
Highly stable and hemocompatible protein now finding use in construction of biomaterials as a result of several strategies for its solubilization.

Biochem/physiol Actions

Protein responsible for the elasticity of many tissues. It is especially important in blood vessels, where it comprises about 50% of the dry tissue weight.

Caution

Forms coacervate at pH 5.0 and 37 °C

Suitability

Suitable for determination of elastolytic activity as described by Keller and Mandi.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Felix Cleemann et al.
Analytical chemistry, 80(11), 4170-4174 (2008-04-25)
A novel fluorescence polarization assay based on the natural fluorophore epicocconone has been developed. This assay allows the rapid and accurate determination of enzyme kinetic parameters as well as inhibition constants through the measurement of fluorescence anisotropy on the actual
Mervyn J Merrilees et al.
Respiratory research, 9, 41-41 (2008-05-20)
COPD is characterised by loss of alveolar elastic fibers and by lack of effective repair. Elastic fibers are assembled at cell surfaces by elastin binding protein (EBP), a molecular chaperone whose function can be reversibility inhibited by chondroitin sulphate of
Wei Li et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(5), 1028-1035 (2013-03-16)
Patients with elastin deficiency attributable to gene mutation (supravalvular aortic stenosis) or chromosomal microdeletion (Williams syndrome) are characterized by obstructive arteriopathy resulting from excessive smooth muscle cell (SMC) proliferation, mural expansion, and inadequate vessel size. We investigated whether rapamycin, an
J Tong et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 45(4), 364-372 (2013-02-12)
The main purpose of the present study is the investigation of gender differences in the biomechanical properties, thrombus age, mass fraction and key clinical factors of abdominal aortic aneurysms (AAAs). A total of 90 AAA samples (78 males and 12
Heath B Henninger et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 31(8), 1226-1233 (2013-04-05)
Elastin is a structural protein that provides resilience to biological tissues. We examined the contributions of elastin to the quasi-static tensile response of porcine medial collateral ligament through targeted disruption of the elastin network with pancreatic elastase. Elastase concentration and
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