C0166

Cys-Gly

≥85% (TLC), suitable fo HPLC

• Synonym(s): L-cysteinyl-glycine
• Empirical Formula (Hill Notation): C₅H₁₀N₂O₃S
• CAS Number: 19246-18-5
• Molecular Weight: 178.21
• MDL number: MFCD00055567
• UNSPSC Code: 12352209
• PubChem Substance ID: 24892240
• NACRES: NA.26

Properties

• product name: Cys-Gly, ≥85% (TLC)
• Assay: ≥85% (TLC)
• form: solid
• technique(s): HPLC: suitable
• storage temp.: −20°C
• SMILES string: NC(CS)C(=O)NCC(O)=O
• InChI: 1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)
• InChI key: ZUKPVRWZDMRIEO-UHFFFAOYSA-N

Description

General description

Cys-Gly, a dipeptide is a catabolic byproduct of glutathione.

Application

Cys-Gly has been used for derivatization by p-hydroxymercury benzoate (PHMB) for calibration of reversed phase chromatography coupled on-line and sequentially with a UV−visible diode array detector (RPLC-DAD).

Biochem/physiol Actions

Cys-Gly is a precursor for glutathione biosynthesis in the neurons. It favors reactive oxygen species generation in the presence of transition metal ions. A normal level of cys-gly is essential for normal cellular function.

L-Cysteine-L-Glycine (Cys-Gly) is used in studies on the homeostasis of glutathione. Cys-Gly is an important molecule for study in the areas of thiol homeostasis, oxidative stress and metals management.

Other Notes

Glutathione fragment

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H319
• Precautionary Statements: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves