53471
FITC-CM-Dextran
average mol wt 70,000
Synonym(s):
FITC-CM-Dextran 70, Fluorescein isothiocyanate–Carboxymethyl–Dextran
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About This Item
UNSPSC Code:
12352116
NACRES:
NA.32
Recommended Products
conjugate
FITC conjugate
Quality Level
form
powder or crystals
mol wt
average mol wt 70,000
composition
carboxymethyl content, 3-7%
extent of labeling
0.001-0.020 mol/mol FITC glucose
technique(s)
permeability assay: suitable
fluorescence
λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0
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General description
FITC-CM-Dextran, also known as Fluorescein isothiocyanate–Carboxymethyl–Dextran, is an anionic fluorescent probe. The carboxyl group provides the negative charge, which improves the overall permeability of the molecule. It is supplied as a yellow powder that is freely soluble in water and electrolyte solutions. FITC-CM-Dextran is insoluble in most organic samples such as ethanol, methanol, acetone, and chloroform. FITC-CM-Dextran is manufactured by reacting selected dextran fractions with an activated carboxymethyl derivative in alkali, whereby O-carboxymethyl groups are introduced along the dextran chain.
Application
FITC-CM-dextran is used to study drug intake and delivery mechanisms in HeLa cell lines. FITC-CM-Dextran was chosen due to its high water solubility and negative charge. It is also a suitable molecule to be used in encapsulation studies for polymersomal drug delivery systems or Ps DDS. FITC-CM-Dextran is a biocompatible molecule used as a starting material in several pharmaceutical and diagnostic applications.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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