ABC213
Anti-phospho ULK1 Antibody (Ser777)
from rabbit, purified by affinity chromatography
Synonym(s):
Serine/threonine-protein kinase ULK1, Serine/threonine-protein kinase Unc51.1, Unc-51-like kinase 1
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
technique(s)
inhibition assay: suitable (peptide)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
phosphorylation (pSer777)
General description
ULK1 or autophagy-related protein 1 homolog (ATG1) is a serine/threonine protein kinase. It is a ubiquitously expressed protein that is highly abundant in the brain, skeletal muscle, and heart. It is involved in the signaling pathway of mTOR receptors leading to the regulation of autophagy in nutrient-deprived cells. mTOR may interact with ULK1 as a complex of ULK1/FIP200/Atg13. ULK1 may play an important role in neuronal development: Elimination of ULK1′s enzymatic activity by targeted disruption of its kinase domain has blocked the outgrowth of neurons in the developing mouse brain, possibly by blocking the ULK1-mediated trafficking of neurotrophins.
Immunogen
KLH-conjugated linear peptide corresponding to a region near the C-terminus of human ULK1 phosphorylated at Ser777.
Application
Anti-phospho ULK1 Antibody (Ser777) is a highly specific rabbit polyclonal antibody, that targets Autophagy-related protein & has been tested in western blotting & Peptide Inhibition Assay.
Evaluated by Western Blotting/Peptide Inhibition Analysis in A431 cell lysate.
Western Blotting/Peptide Inhibition Analysis: 2 µg/mL of this antibody detected phospho ULK1 (Ser777) in 10 µg of A431 cell lysate.
Western Blotting/Peptide Inhibition Analysis: 2 µg/mL of this antibody detected phospho ULK1 (Ser777) in 10 µg of A431 cell lysate.
Quality
Evaluated by Western Blotting in A431 cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected phospho ULK1 (Ser777) in 10 µg of A431 cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected phospho ULK1 (Ser777) in 10 µg of A431 cell lysate.
Target description
~120 kDa observed
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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