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form
liquid
Quality Level
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
shipped in
dry ice
General description
Peroxynitrite (ONOO−) is a powerful oxidant formed by the collision of nitric oxide and superoxide.
Application
Peroxynitrite has been used to induce pericyte contraction in mouse brains. It has also been used for the preparation of positive control nitrated protein standards in immunohistochemical studies.
Biochem/physiol Actions
Peroxynitrite (ONOO−) exhibits bactericidal activity. It promotes cell death and contributes to the signal-transduction process, mitochondrial function, and apoptotic pathway. The formation of peroxynitrite has been associated with the development of various diseases including vascular diseases, ischemia-reperfusion injury, circulatory shock, inflammation, pain, and neurodegeneration.
Quality
Routinely evaluated by treating non-stimulated A431 cells.
Physical form
0.3M NaOH
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2
Storage Class Code
8B - Non-combustible corrosive hazardous materials
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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L Zhu et al.
Archives of biochemistry and biophysics, 298(2), 452-457 (1992-11-01)
Peroxynitrite is a strong oxidant formed by macrophages and potentially by other cells that produce nitric oxide and superoxide. Peroxynitrite was highly bactericidal, killing Escherichia coli in direct proportion to its concentration with an LD50 of 250 microM at 37
A Patel et al.
Journal of endocrinological investigation, 25(8), 675-683 (2002-09-21)
Nitric oxide (NO) is a reactive cell signal that controls vascular tone and is generated by inducible (iNOS), endothelial (eNOS) and neuronal (nNOS) NO synthase (NOS). We hypothesized that NO could be important for growth of thyroid tumors and tested
Oxidative chemistry of peroxynitrite.
Beckman, J S, et al.
Test, 233, 229-240 (1994)
Hongjun Jin et al.
Current protocols in toxicology, Chapter 17, Unit 17-Unit 17 (2012-04-19)
Reactive nitrogen species (RNS) and reactive oxygen species (ROS) are derived as a result of inflammation and oxidative stress and can result in protein modifications. As such, these protein modifications are used as biomarkers for inflammation and oxidative stress. In
Csaba Szabó et al.
Nature reviews. Drug discovery, 6(8), 662-680 (2007-08-02)
Peroxynitrite--the product of the diffusion-controlled reaction of nitric oxide with superoxide radical--is a short-lived oxidant species that is a potent inducer of cell death. Conditions in which the reaction products of peroxynitrite have been detected and in which pharmacological inhibition
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