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Sigma-Aldrich

Anti-FAK Antibody, clone 4.47, Alexa Fluor™ 488 conjugate

clone 4.47, Upstate®, from mouse

Synonym(s):

Anti-FADK, Anti-FADK 1, Anti-FAK, Anti-FAK1, Anti-FRNK, Anti-PPP1R71, Anti-p125FAK, Anti-pp125FAK

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

ALEXA FLUOR™ 488

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4.47, monoclonal

species reactivity

human, rat, mouse

manufacturer/tradename

Upstate®

technique(s)

flow cytometry: suitable
immunocytochemistry: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_005607.3
NM_153831.2

UniProt accession no.

Q05397

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PTK2(5747)

Specificity

p125FAK, does not cross react with Pyk-2

Immunogen

GST fusion protein corresponding to residues 1-423 of human FAK (focal adhesion kinase)

Application

Detect FAK using this Anti-FAK Antibody, clone 4.47, Alexa Fluor 488 conjugate validated for use in FC, WB & IC.
Research Category
Signaling
Research Sub Category
Cytoskeletal Signaling

Quality

Routinely evaluated by immunostaining of 3T3 cells.

Target description

125kDa

Physical form

Protein G Purified

Storage and Stability

1 year at 4°C from date of shipment

Legal Information

ALEXA FLUOR is a trademark of Life Technologies
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Alexa Fluor™ is a registered trademark of Molecular Probes, Inc.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Focal adhesion kinase: in command and control of cell motility.
Mitra, Satyajit K, et al.
Nature Reviews in Molecular and Cell Biology, 6, 56-68 (2005)
Focal adhesion kinase: the first ten years.
Parsons, J Thomas
Journal of Cell Science, 116, 1409-1416 (2003)
Control of motile and invasive cell phenotypes by focal adhesion kinase.
Schlaepfer, David D, et al.
Biochimica et Biophysica Acta, 1692, 77-102 (2004)
David D Schlaepfer et al.
Current opinion in genetics & development, 14(1), 92-101 (2004-04-28)
The ability of intracellular signaling networks to orchestrate a complex biological response such as cell motility requires that individual signaling proteins must act as integrators, responding to multiple extracellular inputs and regulating multiple signaling pathway outputs. In this review, we
FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?
Schaller, Michael D
The Journal of cell biology, 166, 157-159 (2004)
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