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P-038

Supelco

(±)-Phenylpropanolamine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

DL-Norephedrine hydrochloride, Norephedrine hydrochloride, (±)-Phenylpropanolamine hydrochloride, erythro-2-Amino-1-phenyl-1-propanol hydrochloride, DL-erythro-2-Amino-1-phenyl-1-propanol hydrochloride, DL-Phenylpropanolamine hydrochloride

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About This Item

Linear Formula:
C6H5CH(OH)CH(NH2)CH3 · HCl
CAS Number:
154-41-6
Molecular Weight:
187.67
Beilstein:
3914299
EC Number:
200-659-6
MDL number:
MFCD00013019
UNSPSC Code:
41116107
PubChem Substance ID:
329820034
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

194-196 °C (lit.)

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

Cl.C[C@@H](N)[C@@H](O)c1ccccc1

InChI

1S/C9H13NO.ClH/c1-7(10)9(11)8-5-3-2-4-6-8;/h2-7,9,11H,10H2,1H3;1H/t7-,9-;/m1./s1

InChI key

DYWNLSQWJMTVGJ-PRCZDLBKSA-N

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General description

Phenylpropanolamine, also known as Norephedrine, is a stimulant, decongestant, and anorectic drug commonly used in many prescription and over-the-counter cold and cough formulations. The drug is often abused illicitly for its psychoactive and stimulant effects. This Certified Spiking Solution® is applicable for use in many LC-MS/MS or GC/MS applications from clinical chemistry and forensic analysis to urine drug testing.

Application

  • The effects of drug-drug interaction on linezolid pharmacokinetics: A systematic review: This review assesses the interaction of various drugs with linezolid, where (±)-Phenylpropanolamine hydrochloride serves as a reference compound. It provides valuable data on the stability and interaction of pharmaceutical intermediates, highlighting the importance of (±)-Phenylpropanolamine hydrochloride in developing safer drug therapies (Xu et al., 2024).

Biochem/physiol Actions

Mixed-acting sympathomimetic amine.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kuei Hui Chan et al.
Journal of analytical toxicology, 33(3), 162-166 (2009-04-18)
Sho-seiryu-to is one of the most common Traditional Chinese Medicine preparations for the attenuation of colds. Ephedrae Herba is one of the prescriptions of Sho-seiryu-to. The major ingredients of Ephedrae Herba, ephedrines, are banned substances on the World Anti-Doping Agency
Raz Krizevski et al.
Journal of ethnopharmacology, 114(3), 432-438 (2007-10-12)
Khat (Catha edulis Forsk., Celastraceae) is a perennial shrub that was introduced to Israel by Yemenite immigrants. Khat young leaves are chewed as a stimulant. The main stimulating active principles in this plant are the phenylpropylamino alkaloids (-)-cathinone [(S)-alpha-aminopropiophenone], (+)-cathine
Ying Shi et al.
Journal of chromatography. A, 1218(42), 7655-7662 (2011-09-09)
A method for simultaneous determination of eight adulterants including two appetite suppressants, two energy expenditure-enhancing drugs, one diuretic and three cathartics in slimming functional foods by high performance liquid chromatography with electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS) was established. After samples
Saba Kassim et al.
Journal of ethnopharmacology, 140(1), 193-196 (2012-01-17)
Khat chewing amongst the UK communities originating from Yemen and the East African coast is suggested to create dependency through its main stimulant components (cathinone, norephedrine and norpseudoephedrine) on the central nervous system. To validate self-reported khat chewing behaviours by
Richard Hoffman et al.
Journal of ethnopharmacology, 132(3), 554-563 (2010-06-18)
Although there is a rich body of research available regarding the effect of acute and chronic khat dosing in animal models, research on the behavioral and cognitive effects of khat in human subjects is not extensive and several of the
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