56485

N-Hydroxysulfosuccinimide sodium salt

≥98% (HPLC), for peptide synthesis

• Synonym(s): Hydroxy-2,5-dioxopyrrolidine-3-sulfonicacid sodium salt, Sulfo-NHS
• Empirical Formula (Hill Notation): C₄H₄NNaO₆S
• CAS Number: 106627-54-7
• Molecular Weight: 217.13
• Beilstein: 6359129
• MDL number: MFCD00043100
• UNSPSC Code: 12352005
• PubChem Substance ID: 57651582
• NACRES: NA.22

Properties

• product name: N-Hydroxysulfosuccinimide sodium salt, ≥98% (HPLC)
• Assay: ≥98% (HPLC)
• form: powder
• composition: carbon, 21.57-22.68 (anhydrous); nitrogen, 6.28-6.61 (anhydrous)
• reaction suitability: reaction type: Addition Reactions
• impurities: ≤4% water
• application(s): peptide synthesis
• SMILES string: [Na+].ON1C(=O)CC(C1=O)S([O-])(=O)=O
• InChI: 1S/C4H5NO6S.Na/c6-3-1-2(12(9,10)11)4(7)5(3)8;/h2,8H,1H2,(H,9,10,11);/q;+1/p-1
• InChI key: RPENMORRBUTCPR-UHFFFAOYSA-M

Description

Application

N-Hydroxysulfosuccinimide sodium salt is a water-soluble sulfonated analog of N-hydroxysuccinimide. It can undergo a coupling reaction with carboxylic acids in the presence of carbodiimides such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide(EDC) to form hydrophilic N-hydroxysulfosuccinimide active esters. These esters are useful in protein cross-linking experiments.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Sulfo-NHS is used for preparing hydrophilic active esters, e.g. for crosslinking agents

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves