Study of the persistence of the anti-inflammatory effect observed after application of preparations containing organic ultraviolet filters.

Study of the persistence of the anti-inflammatory effect observed after application of preparations containing organic ultraviolet filters.

International journal of pharmaceutics (2014-10-01)

C Couteau, C Chauvet, E Paparis, L J M Coiffard

RÉSUMÉ

Given that previous studies have highlighted the anti-inflammatory nature, which is influenced by UV radiation, of a certain number of ultraviolet filters currently used in Europe, it seemed interesting to evaluate the persistence of this type of effect. The persistence of the anti-inflammatory effect of fourteen preparations, each containing one of the ultraviolet filters authorized by Regulation (CE) No. 1223/2009, and of 10 commercially-available sun products was studied using the phorbol-myristate-acetate test on mice, up to 6 and a half hours after application. We can observe that a benzophenone, oxybenzone, a PABA derivative, octyldimethylPABA and a derivative of cinnamic acid, OMC as well as 3 commercially-available products, display a very marked anti-inflammatory effect at the end of our experimentation phase. The type of effect observed could encourage users to prolong the time that they are exposed to the sun, due to there being no warning signs, namely sunburn.

MATÉRIAUX

Référence du produit

Marque

Description du produit

G7893

Sigma-Aldrich

Glycérol, ACS reagent, ≥99.5%

G5516

Sigma-Aldrich

Glycérol, for molecular biology, ≥99.0%

G7757

Sigma-Aldrich

Glycérol, ReagentPlus^®, ≥99.0% (GC)

P8139

Sigma-Aldrich

Phorbol 12-myristate 13-acétate, ≥99% (TLC), film or powder

90279

Sigma-Aldrich

Triéthanolamine, ≥99.0% (GC)

49781

Sigma-Aldrich

Glycérol solution, 83.5-89.5% (T)

718467

Sigma-Aldrich

Oxyde de titane(IV), nanopowder, 21 nm primary particle size (TEM), ≥99.5% trace metals basis

90335

Sigma-Aldrich

Triéthylamine, BioUltra, ≥99.5% (GC)

S4751

Sigma-Aldrich

Acide stéarique, Grade I, ≥98.5% (capillary GC)

49767

Sigma-Aldrich

Glycérol, BioUltra, for molecular biology, anhydrous, ≥99.5% (GC)

G2025

Sigma-Aldrich

Glycérol, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for electrophoresis, ≥99% (GC)

637254

Sigma-Aldrich

Oxyde de titane(IV), anatase, nanopowder, <25 nm particle size, 99.7% trace metals basis

15523

Sigma-Aldrich

Glycérol, puriss., anhydrous, 99.0-101.0% (alkalimetric)

14027

Sigma-Aldrich

Oxyde de titane(IV), puriss., meets analytical specification of Ph. Eur., BP, USP, 99-100.5%

471283

Sigma-Aldrich

Triéthylamine, ≥99.5%

1295607

USP

Glycérine, United States Pharmacopeia (USP) Reference Standard

232033

Sigma-Aldrich

Oxyde de titane(IV), anatase, powder, 99.8% trace metals basis

14021

Sigma-Aldrich

Oxyde de titane(IV), ReagentPlus^®, ≥99%

G9012

Sigma-Aldrich

Glycérol, ≥99.5%

W252506

Sigma-Aldrich

Glycérol, FCC, FG

49770

Sigma-Aldrich

Glycérol, puriss. p.a., ACS reagent, anhydrous, dist., ≥99.5% (GC)

T0886

Sigma-Aldrich

Triéthylamine, ≥99%

224227

Sigma-Aldrich

Titanium(IV) oxide, rutile, powder, <5 μm, ≥99.9% trace metals basis

248576

Sigma-Aldrich

Oxyde de titane(IV), anatase, powder, −325 mesh, ≥99% trace metals basis

637262

Sigma-Aldrich

Titanium(IV) oxide, rutile, nanopowder, <100 nm particle size, 99.5% trace metals basis

79346

Sigma-Aldrich

Phorbol 12-myristate 13-acétate, synthetic, ≥98.0% (TLC)

634662

Sigma-Aldrich

Titanium(IV) oxide, mixture of rutile and anatase, nanopowder, <100 nm particle size (BET), 99.5% trace metals basis

H36206

Sigma-Aldrich

2-Hydroxy-4-methoxybenzophenone, 98%

W303518

Sigma-Aldrich

Acide stéarique, ≥95%, FCC, FG

700347

Sigma-Aldrich

Titanium(IV) oxide, mixture of rutile and anatase, nanoparticles, <150 nm particle size (volume distribution, DLS), dispersion, 40 wt. % in H₂O, 99.5% trace metals basis