Total synthesis of kottamide E.

Total synthesis of kottamide E.

Chemical communications (Cambridge, England) (2013-02-12)

Thomas B Parsons, Neil Spencer, Chi W Tsang, Richard S Grainger

RÉSUMÉ

The first synthesis of kottamide E, a marine natural product containing a 5,6-dibromoindole linked via a (Z)-enamide to an unusual 1,2-dithiolane-containing amino acid, is reported.

MATÉRIAUX

Référence du produit

Marque

Description du produit

I3408

Sigma-Aldrich

Indole, ≥99%

W259306

Sigma-Aldrich

Indole, ≥99%, FG

92748

Sigma-Aldrich

4-Nitrophenyl 2-(trimethylsilyl)ethyl carbonate, ≥97.0%