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1142108

USP

Clozapine Resolution Mixture

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

Clozapine, 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine

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About This Item

Formule empirique (notation de Hill):
C18H19ClN4
Numéro CAS:
5786-21-0
Poids moléculaire :
326.82
Numéro MDL:
MFCD00153785
Code UNSPSC :
41116107
ID de substance PubChem :
329749444
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

clozapine

Fabricant/nom de marque

USP

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24

InChI

1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3

Clé InChI

QZUDBNBUXVUHMW-UHFFFAOYSA-N

Informations sur le gène

human ... DRD2(1813) , HTR2A(3356)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Clozapine Resolution Mixture USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Clozapine
  • Clozapine Tablets

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301

Classification des risques

Acute Tox. 3 Oral

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Gary Remington et al.
Psychopharmacology, 225(3), 505-518 (2012-11-28)
Clozapine levels are advocated in the monitoring of patients on this drug and have now been used for a number of years. A safety-related threshold has also been proposed, as well as therapeutic lower and upper thresholds. While there has
Benjamin W J Spencer et al.
Pharmacogenomics, 14(15), 1907-1914 (2013-11-19)
Clozapine is a uniquely efficacious antipsychotic drug in treatment-resistant schizophrenia. Its use is restricted due to adverse effects including a rare but dangerous reduction in neutrophils (agranulocytosis) and the mandatory hematological monitoring this entails in many countries. We review the
Saeko Ikai et al.
The Annals of pharmacotherapy, 47(7-8), e31-e31 (2013-06-13)
To report on a patient who was successfully rechallenged with clozapine after perforation of the large intestine and pulmonary embolism post operatively, and provide a literature review on clozapine rechallenge. A 46-year-old Japanese man with treatment-resistant schizophrenia developed constipation and
Rasmus Røge et al.
Schizophrenia research, 140(1-3), 204-213 (2012-07-27)
Clozapine remains the drug of choice for treatment resistant schizophrenia, but is associated with potentially life threatening side effects, including agranulocytosis and myocarditis. Immunological mechanisms may be involved in the development of these side effects or in the unique antipsychotic
Adam P Hill et al.
Molecular pharmacology, 85(5), 769-776 (2014-03-04)
The Kv11.1 potassium channel is the molecular target for the majority of drugs implicated in acquired long QT syndrome, the most common cause of drug-induced sudden cardiac death, and a common reason for drug restriction or withdrawal from the market.
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