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Key Documents

1091221

USP

Captopril disulfide

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

1,1′-[Dithiobis[(2S)-2-methyl-1-oxo-3,1-propanediyl]]bis-L-proline

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About This Item

Formule empirique (notation de Hill):
C18H28N2O6S2
Numéro CAS:
Poids moléculaire :
432.55
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

captopril

Fabricant/nom de marque

USP

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

InChI

1S/C18H28N2O6S2/c1-11(15(21)19-7-3-5-13(19)17(23)24)9-27-28-10-12(2)16(22)20-8-4-6-14(20)18(25)26/h11-14H,3-10H2,1-2H3,(H,23,24)(H,25,26)/t11-,12?,13+,14+/m1/s1

Clé InChI

ZWKRXBCJAUKDCI-KRCVMZOZSA-N

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Captopril disulfide USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Captopril Tablets
  • Captopril
  • Captopril and Hydrochlorothiazide Tablets

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Managing hypertension in patients with renal disease.
J G Porush
Journal of the National Medical Association, 76 Suppl, 24-32 (1984-07-01)
E Ivashkiv
Journal of pharmaceutical sciences, 73(10), 1427-1430 (1984-10-01)
Captopril disulfides and the drug covalently bound to proteins were reduced with tri-n-butylphosphine. After sample purification on an XAD-2 column, captopril was treated with 1-(7-dimethylamino)-4-methyl-2-oxo-2H -1-benzopyran-3-yl)-1H-pyrrole-2,5-dione to form a fluorescent derivative. After acidification, the fluorescent derivative was extracted into toluene
Participation of kinins or prostaglandins in SQ 14,551-induced immediate decrease of blood pressure in anesthetized dogs.
N O'Hara et al.
Japanese journal of pharmacology, 33(2), 485-488 (1983-04-01)
Electrochemical reduction of disulfides.
H Kadin
Methods in enzymology, 143, 257-264 (1987-01-01)
M S Bathala et al.
Journal of pharmaceutical sciences, 73(3), 340-344 (1984-03-01)
A sensitive, quantitative gas chromatographic-electron capture (GC-EC) method for the determination of captopril in blood and captopril and its disulfide metabolites (collectively) in plasma was developed. After addition of an internal standard and N-ethylmaleimide to the biological samples, excess N-ethylmaleimide

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