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1082300

USP

Butoconazole nitrate

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

(±)-1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole mononitrate

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About This Item

Formule empirique (notation de Hill):
C19H17Cl3N2S · HNO3
Numéro CAS:
64872-77-1
Poids moléculaire :
474.79
Numéro MDL:
MFCD00058159
Code UNSPSC :
41116107
ID de substance PubChem :
329749174
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

butoconazole

Fabricant/nom de marque

USP

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

ClC1=C(C(Cl)=CC=C1)SC(CCC2=CC=C(Cl)C=C2)CN3C=CN=C3.O[N+]([O-])=O

InChI

1S/C19H17Cl3N2S.HNO3/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22;2-1(3)4/h1-5,7-8,10-11,13,16H,6,9,12H2;(H,2,3,4)

Clé InChI

ZHPWRQIPPNZNML-UHFFFAOYSA-N

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Description générale

Butoconazole nitrate (BN) is a imidazole used as an antifungal agent.

Application

Butoconazole nitrate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monograph such as Butoconazole Nitrate Vaginal Cream.

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Conseils de prudence

P301 + P312 + P330

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Meng-meng Jia et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 34(3), 431-436 (2014-06-19)
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of butoconazole in human plasma. Human plasma samples of 0.2 μL were pretreated by a single step protein precipitation procedure and analyzed using a high performance
J B Jacobson et al.
Acta obstetricia et gynecologica Scandinavica, 64(3), 241-244 (1985-01-01)
The continuously increasing incidence of vulvovaginal candidiasis necessitated a search for novel therapeutic modalities. Butoconazole nitrate (BN) a new imidazole, has been singled out for clinical studies since, in experimental vaginal candidiasis, it proved more effective than either miconazole nitrate
D Brown et al.
The Journal of reproductive medicine, 44(11), 933-938 (1999-12-10)
To compare the safety and efficacy of a single vaginal dose of a butoconazole nitrate 2% bioadhesive, sustained-release cream* (butoconazole 1-BSR) with a seven-day schedule of miconazole nitrate vaginal cream 2% (miconazole 7). The clinical trial was conducted according to
E Rachev
Akusherstvo i ginekologiia, 46(2), 25-27 (2007-05-02)
to have a personal experience concerning the therapeutic characteristics of the new product GYNAZOL (Gedeon Richter, Ltd)--5 g. vaginal cream for treatment of vulvo-vaginal candidosis (VVC). 31 women in reproductive and climacteric age suffering from acute or chronic VVC. inquiry
A Nikolov et al.
Akusherstvo i ginekologiia, 46(9), 23-26 (2008-07-23)
To study the therapeutic application of Gynazol in cases of recurrent vaginal Candida infections during the last trimester of pregnancy. 28 pregnant women in third trimester with recurrent vaginal Candida infection were included in the study. All cases were treated
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