SRP8010

GPX1 human

recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)

• Synonyme(s) : Cellular glutathione peroxidase, Death receptor 6, GSHPx-1, Glutathione peroxidase 1
• Numéro CAS: 1451392-36-1
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: human
• Produit recombinant: expressed in E. coli
• Étiquette/Marqueur: His tagged
• Pureté: >90% (SDS-PAGE)
• Forme: lyophilized
• Poids mol.: ~25 kDa by SDS-PAGE
• Conditionnement: pkg of 10 μg
• Conditions de stockage: avoid repeated freeze/thaw cycles
• Impuretés: <1 EU/μg endotoxin, tested
• Couleur: white
• Numéro d'accès UniProt: P07203
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: human ... GPX1(2876)

Description

Description générale

GPX1 (glutathione peroxidase 1) is a selenoprotein and the gene is mapped to human chromosome 3p21.3. It is present in the cytoplasm and is widely expressed.

Actions biochimiques/physiologiques

GPX1 (glutathione peroxidase 1) is responsible for scavenging free radicals and derivatives. GPXs reduces lipid hydroperoxides to the corresponding alcohols as well as free hydrogen peroxide to water. Mutations in the GPX1 gene are associated with nonalcoholic fatty liver disease (NAFLD) susceptibility. Mutation in GPX1 at C594T is linked with oxidative stress-associated disorders, including prostate cancer and bladder cancer.

Forme physique

Lyophilized from 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl, 1 mM DTT.

Reconstitution

Reconstitute with 100 μL deionized water.

Autres remarques

Human GPX1 (aa 1-201) is fused at the C-terminus to a His-tag.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable