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Key Documents

SRP6552

Sigma-Aldrich

TGF-β3 from mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

Synonyme(s) :

Transforming growth factor beta-3

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About This Item

Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

mouse

Produit recombinant

expressed in E. coli

Pureté

≥98% (SDS-PAGE)

Forme

liquid

Poids mol.

25.5 kDa

Conditionnement

pkg of 5 μg
pkg of 50 μg
pkg of 500 μg

Concentration

0.25 mg/mL

Impuretés

≤1 EU/μg endotoxin (LAL test)

Numéro d'accès UniProt

P04202 

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

mouse ... TGF-beta-1(21803)

Description générale

TGFβ3 (transforming growth factor β3) is one of the three isoforms of mammalian TGFβ, and all the isoforms share high sequence similarity at the active domains, with TGFβ3 showing highest similarity with TGFβ1.
Recombinant mouse TGF-β3 is a non-glycosylated, disulfide-linked homodimer, containing two 112 amino acid chains, with a total molecular weight of 25.5kDa.
The TGFB1 gene is mapped to human chromosome 19q13.2. The encoded protein is an anti-inflammatory cytokine.

Actions biochimiques/physiologiques

TGFβ3 (transforming growth factor β3) shows higher expression levels during late stage tumors, and hence, is thought to be associated with tumorigenesis. However, studies also show that in skin, breast, oral and gastric mucosa and other types of tissue, this protein confers protection against tumorigenesis. It plays crucial role in the development of systems such as heart, breast and lung. It is essential for mouse embryonic palate fusion, as inactivation results in non-fusion of palatal shelves. This protein plays a crucial role in orofacial development and is essential for excisional wound repair in vivo.

Forme physique

0.25 mg/mL solution containing 20% ethanol and 0.12% acetic acid (AcOH) .

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

does not flash

Point d'éclair (°C)

does not flash

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

TGF-beta3 and cancer: a review.
Laverty HG et al
Cytokine & Growth Factor Reviews, 20(4), 305-317 (2009)
Transforming growth factor Beta 3 is required for excisional wound repair in vivo.
Le M et al
PLoS ONE, 7(10), e48040-e48040 (2012)
Peripheral regulatory T cells and anti-inflammatory cytokines in children with juvenile idiopathic arthritis
Sznurkowska K, et al.
Acta Biochimica Polonica, 65(1), 1908-1916 (2018)
Identification of PAK4 as a putative target gene for amplification within 19q13.12-q13.2 in oral squamous-cell carcinoma
Begum A, et al.
Cancer Science, 100(10), 1908-1916 (2009)
Zhaoyang Liu et al.
eLife, 10 (2021-07-29)
Adolescent idiopathic scoliosis (AIS) is the most common spine disorder affecting children worldwide, yet little is known about the pathogenesis of this disorder. Here, we demonstrate that genetic regulation of structural components of the axial skeleton, the intervertebral discs, and

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