SRP6518

Plasminogen from human plasma

≥95% (SDS-PAGE)

• Synonyme(s) : PLG
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: human
• Pureté: ≥95% (SDS-PAGE)
• Forme: lyophilized
• Poids mol.: 90.0 – 92.0 kDa
• Conditionnement: pkg of 1 mg
• Numéro d'accès UniProt: P00747
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: human ... PLG(5340)

Description

Description générale

Plasminogen is the inactive precursor of plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration.
Plasminogen is encoded by the gene mapped to human chromosome 6q26–27. The encoded protein is characterized with a leader, kringle and protease domains.

Actions biochimiques/physiologiques

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. It cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. Plasmin is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β).

Forme physique

Lyophilized from 20 mM Tris-HCl, pH 7.5, with 2 mM EDTA.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable