SRP4171
IL-15 from mouse
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonyme(s) :
IL 15, IL-T, Interleukin 15
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About This Item
Produits recommandés
Source biologique
mouse
Produit recombinant
expressed in E. coli
Pureté
≥98% (HPLC)
≥98% (SDS-PAGE)
Forme
lyophilized
Poids mol.
~13.3 kDa
Conditionnement
pkg of 10 μg
Conditions de stockage
avoid repeated freeze/thaw cycles
Impuretés
endotoxin, tested
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Informations sur le gène
mouse ... Il15(16168)
Description générale
IL15 (interleukin 15) protein is a short-chain α-helical bundle type 1 T cell-stimulating cytokine. It is a pleiotropic cytokine belonging to the cytokine receptor γ chain family, and is expressed by dendritic cells (DCs), epithelial cells, macrophages, monocytes, and fibroblasts. IL15, along with its receptor IL15Rα, are co-expressed majorly by activated monocytes and DCs (dendritic cells). Recombinant mouse IL-15 is a 13.3 kDa protein containing 115 amino acid residues.
Actions biochimiques/physiologiques
IL15 (interleukin 15) and IL2 are the only two known cytokine till date that bind to T-cells through IL-2Rβ (IL2 receptorβ). It interacts with lymphocytes via the heterotrimeric IL-15 receptor (IL-15R) composed of IL-15Rα, IL-2 receptor beta (IL-2Rβ), and IL-2 receptor gamma (IL-2Rγ). Since, IL-2R and IL-15R have common subunits, it is supposed that IL2 and IL15 perform similar functions, such as induction of lymphocyte activation and proliferation in vitro, and apoptosis of activated lymphocytes (AICD). However, unlike IL2, IL15 mimics the function of IFN I (interferon) by potently and selectively activating memory-phenotype CD44hi CD8+ cells.
Forme physique
Lyophilized from 10 mM Tris, pH 8.0.
Reconstitution
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 μg/μL. The solution can then be diluted into other aqueous buffers.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes.
Yu H, et al.
PLoS ONE, 10(11) (2015)
Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells.
Schluns KS, et al.
Journal of Immunology, 168(10), 4827-4831 (2002)
Anne L Ruiz et al.
Nature communications, 5, 5150-5150 (2014-10-07)
Following microbial pathogen invasion, one of the main challenges for the host is to rapidly control pathogen spreading to avoid vital tissue damage. Here we report that an effector CD8(+) T-cell population that expresses the marker NK1.1 undergoes delayed contraction
The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapy.
Waldmann TA
Cancer immunology research, 3(3), 219-227 (2015)
Ai Omi et al.
European journal of immunology, 44(9), 2638-2647 (2014-07-06)
Mature NK cells are heterogeneous as to their expression levels of cell surface molecules. However, the functional differences and physiological roles of each NK-cell subset are not fully understood. In this study, we report that based on the Ly6C expression
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