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Merck
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Key Documents

SRP2102

Sigma-Aldrich

TNFα, low endotoxin, His tagged human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Synonyme(s) :

DIF, TNF-alpha, TNFA, TNFSF2

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About This Item

Code UNSPSC :
12352200
Nomenclature NACRES :
NA.26

Source biologique

human

Produit recombinant

expressed in E. coli

Pureté

≥80% (SDS-PAGE)

Forme

frozen liquid

Poids mol.

~21 kDa

Conditionnement

pkg of 10 μg

Conditions de stockage

avoid repeated freeze/thaw cycles

Concentration

1250 μg/mL

Couleur

clear colorless

Numéro d'accès NCBI

NM_000594

Numéro d'accès UniProt

P01375

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... TNF(7124)

Description générale

Tumor necrosis factor α (TNFα or TNFSF2) is encoded by the gene mapped to human chromosome 6p21.33.

Actions biochimiques/physiologiques

Tumor necrosis factor α (TNFα or TNFSF2) is produced by many different cell types including activated monocytes, fibroblasts, endothelial cells, macrophages, T-cells, B-lymphocytes, granulocytes, smooth muscle cells, eosinophilis, chondrocytes and other cell types. It functions as a cytokine involved in cell proliferation, differentiation, apoptosis, lipid metabolism and coagulation. High level of TNFα leads to the development of inflammatory responses that are hallmarks of many diseases including autoimmune diseases, insulin resistance and cancer. The active form of TNFα (18 kDa) is generated by the cleavage of an Ala-Val bond between residues 76-77 of the precursor protein.

Forme physique

Clear and colorless frozen liquid solution

Notes préparatoires

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Hao Zhu et al.
Frontiers in cell and developmental biology, 9, 642437-642437 (2021-03-26)
Low back pain is tightly associated with intervertebral disc degeneration (IVDD) and aberrant nucleus pulposus (NP) is a critical cause. miRNAs N6-methyladenosine (m6A) modification accounts for the TNF-α-induced senescence of NP cells. The aim of this study was to investigate
A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels.
Bos SD
European Journal of Human Genetics, 18, 953-959 (2010)
Alasdair J Edgar et al.
Respiratory research, 7, 1-1 (2006-01-05)
To elucidate further the pathogenesis of sporadic, idiopathic pulmonary arterial hypertension (IPAH) and identify potential therapeutic avenues, differential gene expression in IPAH was examined by suppression subtractive hybridisation (SSH). Peripheral lung samples were obtained immediately after removal from patients undergoing
Bharat B Aggarwal
Nature reviews. Immunology, 3(9), 745-756 (2003-09-02)
Two different tumour-necrosis factors (TNFs), first isolated in 1984, were found to be cytotoxic to tumour cells and to induce tumour regression in mice. Research during the past two decades has shown the existence of a superfamily of TNF proteins
The TNF and TNF receptor superfamilies: integrating mammalian biology.
R M Locksley et al.
Cell, 104(4), 487-501 (2001-03-10)

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