SML1446

HTH-01-015

≥98% (HPLC)

• Synonyme(s) : 5,13-Dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one
• Formule empirique (notation de Hill): C₂₆H₂₈N₈O
• Numéro CAS: 1613724-42-7
• Poids moléculaire : 468.55
• Numéro MDL: MFCD28167816
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825886
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to light brown
• Solubilité: DMSO: 5 mg/mL, clear (warmed)
• Température de stockage: −20°C
• Chaîne SMILES: CC1=C2C(N(C)C(C=C(C=CC=C3)C3=C4)=C4C(N2C)=O)=NC(NC5=CN(C6CCNCC6)N=C5)=N1
• InChI: 1S/C26H28N8O/c1-16-23-24(31-26(29-16)30-19-14-28-34(15-19)20-8-10-27-11-9-20)32(2)22-13-18-7-5-4-6-17(18)12-21(22)25(35)33(23)3/h4-7,12-15,20,27H,8-11H2,1-3H3,(H,29,30,31)
• Clé InChI: CHSDJDLAKKAWCI-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

HTH-01-015 is a potent and selective inhibitor of NUAK1 kinase, a member of the AMPK family that are that are activated by the LKB1 (liver kinaseB1) tumour suppressor kinase and involved in development and proliferation. HTH-01-015 has an IC₅₀ of 100 nM for NUAK1, >100-fold higher than NUAK2, and has no significant inhibition of 139 other kinases tested, including ten AMPK-related kinase family members. Treatment with HTH-01-015 was found to suppress proliferation, restricting cells from entering into mitosis.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable